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Rabbit Anti-TNPO3 Polyclonal Antibody#abs137774

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Description

Catalog-specification	Delivery time	USD price
abs137774-100ug	1-2 Weeks	301.0
abs137774-50ug	1-2 Weeks	201.0

Overview
catalog	abs137774
Other names	Transportin 3, also known as TNPO3, Imp12, Importin 12, Importin-12, IPO12, MTR10A, or TRN-SR2, is an important protein involved in the transport of molecules within cells. Transportin 3 belongs to the karyopherin family of proteins and specifically acts as a transport receptor for certain proteins and RNAs. Studies have shown that Transportin 3 regulates various cellular processes such as cell growth and differentiation, nuclear import of transcription factors, and DNA damage repair. Its dysregulation has been linked to various diseases such as cancer and viral infections. Thus, understanding the roles and regulation of Transportin 3 is essential for developing new treatments for these diseases.
Source	Rabbit
Specificity	The TNPO3 Antibody is designed to identify total TNPO3 at its natural levels in the body.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	TNPO3
Application	You can use the dilution ratio of 1:1000 to 1:3000 for Western blotting, 1:200 for IHC, and 1:20000 to 1:40000 for ELISA with peptides. It is important to note that these dilution ratios may need to be optimized for particular samples and experimental conditions.
Immunogen	A synthesized peptide derived from human TNPO3.
MW	104 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography in order to purify the antiserum. Please provide a similar content by reorganizing the given text information, while keeping the content rooted in the original text.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's integrity, it is recommended to keep it stored at a temperature of -20 °C for a period of one year. However, caution should be exercised to avoid subjecting it to repeated cycles of freezing and thawing. This would help to guarantee optimal performance and effectiveness of the product.
Storage buffer	This product contains rabbit IgG dissolved in a solution of phosphate buffered saline, with a pH of 7.4, and 150mM NaCl. It also includes 0.02% sodium azide and 50% glycerol for stability during storage at -20 °C. This product has a shelf life of 12 months from the date of receipt, ensuring that you have ample time to use it in your research.
Target
Background	Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains.
Tissue specificity	Expressed in skeletal muscle.
Celluar localization	Nucleus;
UniPort	Q9Y5L0