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Rabbit Anti-TNFRSF10C Polyclonal Antibody#abs135791

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Description

Catalog-specification	Delivery time	USD price
abs135791-100ug	1-2 Weeks	301.0
abs135791-50ug	1-2 Weeks	201.0

Overview
catalog	abs135791
Description	The regulation of apoptosis in various physiological systems is greatly influenced by the tumor necrosis factor receptor family, which consists of several members such as TNF-RI, Fas, DR3, DR4, DR5, and DR6 (1,2). These receptors are activated by different cytokines including TNF, FasL, and TRAIL. They possess a highly preserved extracellular region containing cysteine-rich repeats and an intracellular region known as the death domain (DD), which spans roughly 80 amino acids. The DD plays a crucial role in transmitting the death signal by enlisting other adaptor proteins (FADD, TRADD, RIP) that also contain the DD to form the death-inducing signaling complex (DISC), leading to the activation of caspases. To regulate death receptor signaling and prevent apoptosis, a family of decoy receptors (DcR1, DcR2, and DcR3) exist. These decoy receptors lack a cytoplasmic DD but are able to hinder death receptor-mediated apoptosis by competing for ligand binding (3-5). The expression of decoy receptors offers a mechanism through which certain types of cancer can control apoptosis and influence chemosensitivity (6-8).
Other names	Decoy TRAIL receptors, also known as antagonist decoy receptors for TRAIL/Apo 2L, have multiple names including CD263, cytotoxic TRAIL receptor 3, DCR1, DCR1 TNFR, decoy receptor 1, and decoy TRAIL receptor without death domain. Other aliases include LIT, lymphocyte inhibitor of TRAIL, MGC149501, MGC149502, TNF-related apoptosis-inducing ligand receptor 3, TNF-re ated apoptosis-inducing ligand receptor 3, TNFRSF10C, TRAIL R3, TRAIL receptor 3, TRAILR3, TRID, tumor necrosis factor receptor superfamily member 10C, and tumor necrosis factor receptor superfamily member 10c decoy without an intracellular domain. These various names are used to refer to the same decoy receptor for TRAIL/Apo 2L, which acts as a regulator of TRAIL-induced cell death. By rearranging and rephrasing the given information, it can be stated that the decoy TRAIL receptor, designated with different names, serves as an antagonist for TRAIL/Apo 2L and plays a role in modulating TRAIL-induced apoptosis.
Source	Rabbit
Specificity	The TNFRSF10C Antibody is capable of detecting the complete quantity of endogenous TNFRSF10C present in a sample. This information can be used to gain a deeper understanding of the protein's role and function. It should be noted that the antibody is designed to identify total TNFRSF10C levels specifically, and not the presence of any variants or modifications.
Species Reactivity	Human;Rat
Antigen	TNFRSF10C
Application	： ELISA(peptide)1:20000-1:40000，WB1:500-1:2000，IHC1:50-1:200。
Immunogen	A synthesized peptide derived from human TNFRSF10C.
MW	27kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
Tissue specificity	Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
Posttranslational modification	N-glycosylated and O-glycosylated.
Celluar localization	Plasma Membrane;
UniPort	O14798