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Rabbit Anti-TLK1 Polyclonal Antibody#abs135094

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Description

Catalog-specification	Delivery time	USD price
abs135094-100ug	1-2 Weeks	301.0
abs135094-50ug	1-2 Weeks	201.0

Overview
catalog	abs135094
Other names	The various names for the protein TLK1, or tousled-like kinase 1, include PKU beta, PKU-beta, serine threonine protein kinase, and SNARE protein kinase SNAK. TLK1 is a serine/threonine protein kinase that plays a role in many cellular processes, including DNA replication and repair. This protein kinase has been linked to various diseases, such as cancer, and may serve as a therapeutic target in the future. Despite its many names, TLK1 remains a fascinating protein with crucial biological functions yet to be fully elucidated.
Source	Rabbit
Specificity	The TLK1 Antibody is capable of detecting total TLK1 levels that occur within the body's natural system. This antibody targets endogenous TLK1, providing accurate measurements of the total TLK1 protein content within the individual.
Species Reactivity	Human
Antigen	TLK1
Application	WB 1:500~1:1000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	87 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum. To ensure a highly pure and effective product, this process was necessary and critical to achieving its desired function.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for this product is at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	The Rabbit IgG is suspended in a solution of phosphate buffered saline at pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol for stability. It is recommended that the solution be stored at a temperature of -20 °C to maintain its efficacy. The product has a shelf life of 12 months from the date of purchase, provided that it is stored as instructed.
Target
Background	Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Tissue specificity	Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
Celluar localization	Nucleus;
UniPort	Q9UKI8