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Rabbit Anti-THRAP3 Polyclonal Antibody#abs138413

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Description

Catalog-specification	Delivery time	USD price
abs138413-100ug	1-2 Weeks	301.0
abs138413-50ug	1-2 Weeks	201.0

Overview
catalog	abs138413
Other names	FLJ22082, also known as Thyroid Hormone Receptor Associated Protein 3 or Thrap3, is a critical component of the Thyroid Hormone Receptor-Associated Protein Complex. This complex is essential for regulating thyroid hormone signaling and plays a pivotal role in the development and function of various organs and tissues. The TRAP150_HUMAN protein, which is encoded by the Thrap3 gene, interacts with other proteins in the complex to modulate gene expression and transcriptional activity. This protein is particularly important in regulating metabolic homeostasis and energy expenditure, making it a promising target for developing therapies to combat metabolic disorders. The detailed understanding of the Thrap3 gene and its protein product will help researchers develop more effective interventions to address a wide range of health issues, including obesity, diabetes, and other metabolic disorders.
Source	Rabbit
Specificity	The THRAP3 Antibody has the ability to recognize and measure the natural amounts of total THRAP3 present in a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Sheep;Bovine;Dog
Antigen	THRAP3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human THRAP3.
MW	109kDa
Properties
Concentration	1mg/ml
purification	We used SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. Please rearrange the given content to generate a highly similar content while ensuring that it is based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles.
Storage buffer	The provided information describes the storage conditions and stability of Rabbit IgG in phosphate buffered saline (PBS), pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the Rabbit IgG at -20 °C, and it will remain stable for 12 months from the date of receipt.
Target
Background	Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).
Tissue specificity	Ubiquitous.
Posttranslational modification	ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
Celluar localization	Extracellular region or secreted;Nucleus;
UniPort	Q9Y2W1