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Rabbit Anti-THPO Polyclonal Antibody#abs136160

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Description

Catalog-specification	Delivery time	USD price
abs136160-100ug	1-2 Weeks	301.0
abs136160-50ug	1-2 Weeks	201.0

Overview
catalog	abs136160
Description	The process of megakaryocytopoiesis is vital for the production of platelets in the body. A protein, encoded by this particular gene, plays a crucial role in the growth and maturation of megakaryocytes, which are responsible for thrombopoiesis. This protein serves as a humoral growth factor and acts as a ligand for the product of myeloproliferative leukemia virus oncogene (MLP/C_MPL). Mutations in this gene can lead to thrombocythemia 1, a condition characterized by an excessive number of platelets in the blood. Several transcript variants are produced via alternate splicing of this gene. These variants contribute to the diverse functions performed by this protein in the body. Overall, this gene plays a crucial role in ensuring proper platelet production and function, and any disruptions to its function can result in severe health consequences.
Other names	Thrombopoietin, also known as C-mpl ligand, megakaryocyte colony-stimulating factor, megakaryocyte growth and development factor, and megakaryocyte stimulating factor, is a glycoprotein hormone that regulates the production and differentiation of megakaryocytes and platelets. It is encoded by the THPO gene in humans and is also known as Myeloproliferative leukemia virus oncogene ligand or MPL ligand. Thrombopoietin is produced mainly by the liver and kidneys and stimulates the proliferation and differentiation of megakaryocyte progenitor cells in the bone marrow. It acts on the thrombopoietin receptor, also known as MPL, which is expressed on the surface of megakaryocyte progenitor cells and platelets. Thrombopoietin promotes the survival, maturation, and platelet production of these cells, as well as their release into the bloodstream. Thrombopoietin has been shown to be effective in the treatment of thrombocytopenia, a condition characterized by low platelet counts, caused by bone marrow failure or chemotherapy. Several forms of thrombopoietin are available for clinical use, including romiplostim and eltrombopag, which bind to the thrombopoietin receptor and mimic the effects of thrombopoietin. Other names for thrombopoietin include MGC163194, MKCSF, ML, MPLLG, Prepro thrombopoietin, THCYT1, Thrombopoietin nirs variant 1, and TPO.
Source	Rabbit
Specificity	The THPO Antibody is capable of detecting the total THPO levels that exist naturally within an organism. By using this antibody, researchers can gain a better understanding of the mechanisms that govern the production and regulation of THPO, which plays a vital role in a number of different biological processes. This information can be used to develop new treatments for conditions that affect the production or function of THPO. Overall, the THPO Antibody is an important tool for investigating the complex workings of the body and expanding our understanding of how it functions on a molecular level.
Species Reactivity	Human;Mouse;Rat
Antigen	THPO
Application	The recommended dilutions for WB are between 1:500 and 1:2000, for IHC you should use a dilution of 1:50 to 1:200, while for ELISA that involves peptide, the appropriate dilution range is from 1:20000 to 1:40000. Use these guidelines to ensure accurate and reliable results when conducting experiments. It is important to note that proper dilution can vary depending on the sample type and antibody used, so confirm the optimal dilution for each experiment individually.
Immunogen	A synthesized peptide derived from human THPO.
MW	38kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Celluar localization	Extracellular region or secreted;
UniPort	P40225