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Rabbit Anti-TFPI Polyclonal Antibody#abs136031

Please note that the displayed price is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis of extracts of variouscell lines, using TFPI antibody. This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs136031-100ug	1-2 Weeks	301.0
abs136031-50ug	1-2 Weeks	201.0

Please note that the displayed price is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs136031
Description	This gene is responsible for producing a protease inhibitor that plays a crucial role in regulating the tissue factor (TF)-dependent pathway involved in blood coagulation. Blood coagulation begins with the formation of a complex between factor VIIa and TF, which then activates other proteases (factors IX and X) in a sequential manner, ultimately leading to the creation of a fibrin clot. The protein produced by this gene acts as an inhibitor for the activated factor X and VIIa-TF proteases, establishing a self-regulatory mechanism. It is worth noting that the protein is glycosylated and primarily found in the vascular endothelium and plasma, existing both in its free form and bound to plasma lipoproteins. Multiple variations of this gene, resulting from alternative splicing of its transcripts, have been identified. However, some of these variants have not yet been fully characterized. This information has been provided by RefSeq in July 2008.
Other names	TFPI, also known as tissue factor pathway inhibitor or lipoprotein-associated coagulation inhibitor, is a protein involved in inhibiting blood clotting. It is also referred to as anti-convertin, EPI, extrinsic pathway inhibitor, LACI and TFI. The human TFPI is encoded by the TFPI1 gene. This protein plays a crucial role in regulating the extrinsic pathway of coagulation. Mutations in this gene cause an increased risk of thrombosis. TFPI1 is a powerful anticoagulant and its deficiency is associated with a predisposition to clotting disorders. In summary, TFPI is a vitally important protein involved in preventing blood clotting disorders and maintaining the proper function of the body's circulatory system.
Source	Rabbit
Specificity	The TFPI Antibody has the ability to recognize the total TFPI levels present within the body. This means that it can accurately detect and measure the amount of endogenous TFPI that is naturally produced.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit
Antigen	TFPI
Application	The dilution ratios for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA with peptide range from 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human TFPI.
MW	35kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLinkâ„¢ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 Â°C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 Â°C.Stable for 12 months from date of receipt.
Target
Background	Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Tissue specificity	Mostly in endothelial cells.
Posttranslational modification	O-glycosylated.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Plasma Membrane;
UniPort	P10646