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Rabbit Anti-TCTN3 Polyclonal Antibody#abs135643

Please note that the price mentioned above is provided for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. Western blot analysis of various cell linesusing TCTN3 antibody. This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs135643-100ug	1-2 Weeks	301.0
abs135643-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is provided for your reference only. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs135643
Description	Chromosome 10q24.1 is the location of the gene that encodes Tect3 (tectonic-3), also known as TCTN3. Tect3 is a single-pass type I membrane protein consisting of 607 amino acids. It belongs to the tectonic protein family and has four alternatively spliced isoforms. Tect3 plays a role in apoptosis regulation and interacts with MKS1. The gene responsible for Tect3 spans approximately 31,560 bases. Human chromosome 10 (10q24.1) is quite significant, encompassing nearly 135 million base pairs and housing around 1,200 genes. It accounts for approximately 4.5% of the entire human genome. Chromosome 10 contains various protein-coding genes, including those responsible for chemokines, cadherins, excision repair proteins, early growth response factors (Egrs), and fibroblast growth receptors (FGFRs). Numerous genetic disorders are associated with genes on chromosome 10. These include Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman's syndrome, Cowden syndrome, Cockayne syndrome, multiple endocrine neoplasia type 2, and porphyria. Additionally, chromosome 10 is linked to tetrahydrobiopterin deficiency and several syndromes characterized by defects in skull and facial bone fusion.
Other names	C10orf61 is also known as Chromosome 10 open reading frame 61. It is sometimes referred to as DKFZP564D116 or JBTS18. Other names for this gene include OFD4, TCTN3, and TECT3. The corresponding protein is called TECT3 or Tectonic 3. It is important to note that TECT3 exists in a precursor form before it is fully processed. This gene belongs to the Tectonic family, specifically Tectonic-3.
Source	Rabbit
Specificity	The TCTN3 Antibody is capable of measuring the total amount of TCTN3 present within cells. It is highly sensitive and able to accurately detect endogenous levels of this protein. By using this antibody, researchers will be able to gain a deeper understanding of the role that TCTN3 plays in various cellular processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Bovine
Antigen	TCTN3
Application	The dilution ratios for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA with peptide range from 1:20000 to 1:40000. These dilution ratios indicate the amount of sample to be mixed with the assay reagents for optimal results. It is important to follow these instructions carefully to ensure accurate and reliable experimental outcomes. By adjusting the dilution ratios within the specified ranges, researchers can fine-tune the sensitivity and specificity of the assays to meet their specific experimental needs.
Immunogen	A synthesized peptide derived from human TCTN3.
MW	66kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regulation. Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway.
Celluar localization	Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q6NUS6