Rabbit Anti-TBXAS1 Polyclonal Antibody#abs135048
Please note that the price provided is only for your reference. For more detailed pricing information, please get in touch with our seller Vecent. We would like to emphasize that the exact cost may differ from the one mentioned earlier, hence it is advisable to confirm the pricing with Vecent...
Description
| Catalog-specification | Delivery time | USD price |
abs135048-50ug | 1-2 Weeks | 201.0 |
abs135048-100ug | 1-2 Weeks | 301.0 |
Please note that the price provided is only for your reference. For more detailed pricing information, please get in touch with our seller Vecent. We would like to emphasize that the exact cost may differ from the one mentioned earlier, hence it is advisable to confirm the pricing with Vecent before making any purchase decisions. Thank you.
| Overview | |
catalog | abs135048 |
| Other names | Thromboxane A synthase 1 (TXAS) is an enzyme encoded by the CYP5A1 gene within the Cytochrome P450 family. TXAS is also known as cytochrome P450 5A1, platelet cytochrome P450 subfamily V, and GHOSAL. Its function is to catalyze the conversion of prostaglandin H2 into thromboxane A2 (TXA2), a potent vasoconstrictor and platelet aggregator. TXA2 is involved in many physiological processes, including hemostasis, inflammation, and thrombosis. In humans, TXAS is mainly expressed in platelets, where it contributes to platelet activation and aggregation. It is also expressed in vascular smooth muscle cells, endothelial cells, and macrophages, where it has been implicated in the pathogenesis of cardiovascular disease. Dysregulation of TXAS activity has been linked to various diseases, including atherosclerosis, hypertension, and myocardial infarction. As such, TXAS has emerged as a potential therapeutic target for the prevention and treatment of these conditions. In summary, TXAS is a key enzyme involved in the synthesis of the vasoconstrictor and platelet aggregator TXA2. Its dysregulation has been implicated in the pathogenesis of various cardiovascular diseases, making it a promising therapeutic target for intervention. |
| Source | Rabbit |
| Specificity | The presence of total TBXAS1 can be effectively determined using the TBXAS1 Antibody, which is capable of detecting endogenous levels of the protein. To create a highly similar content based on the original information, the following rearrangement can be made: "By detecting endogenous levels of total TBXAS1, the TBXAS1 Antibody proves to be a reliable tool for accurately assessing the protein's presence." |
| Species Reactivity | Human |
| Antigen | TBXAS1 |
| Application | You can use diluted sample concentrations ranging from 1:500 to 1:1000 for Western Blotting, and dilutions ranging from 1:100 to 1:500 for Immunofluorescence or Immunocytochemistry. For ELISA assays using peptides, a dilution of 1:20000 to 1:40000 is recommended for optimal results. It's important to ensure that your dilutions and concentrations are accurate to obtain reliable and accurate data. |
| Immunogen | A synthesized peptide. |
| MW | 0 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography to achieve purification. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To preserve its quality, it is advised to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to frequent cycles of freezing and thawing. |
| Storage buffer | Storage Conditions: The Rabbit IgG is formulated in a solution of phosphate buffered saline (PBS) with a pH of 7.4. It contains 150mM NaCl and 0.02% sodium azide to maintain stability. Additionally, it is supplemented with 50% glycerol for preservation. To ensure optimal storage, the Rabbit IgG should be stored at a temperature of -20 °C. Stability: The Rabbit IgG is guaranteed to remain stable for a period of 12 months from the date of receipt. It is important to note that the stability of the product is highly dependent on proper storage conditions. Therefore, it is crucial to adhere to the recommended storage temperature and prevent any temperature fluctuations that may compromise the integrity of the product. By following the appropriate storage guidelines, you can effectively maintain the quality and functionality of the Rabbit IgG for a significant period, allowing you to utilize it in various applications as needed. |
Target | |
Background | (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate. |
| Tissue specificity | Platelets, lung, kidney, spleen, macrophages and lung fibroblasts. |
| Celluar localization | Endoplasmic reticulum; |
| UniPort | P24557 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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