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Rabbit Anti-TACSTD1 Polyclonal Antibody#abs135831

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Description

Catalog-specification	Delivery time	USD price
abs135831-100ug	1-2 Weeks	301.0
abs135831-50ug	1-2 Weeks	201.0

Overview
catalog	abs135831
Description	Epithelial cell adhesion and activating molecule (EpCAM/CD326) is a transmembrane glycoprotein responsible for mediating Ca2+-independent, homophilic adhesions on the basolateral surface of most epithelial cells. Although EpCAM is not expressed in adult squamous epithelium, it is highly expressed in adeno and squamous cell carcinomas, making it a valuable marker of epithelial and tumor tissue. In fact, EpCAM was one of the first tumor-associated antigens identified through research studies, and it has since been shown to be highly expressed in cancer cells, as evidenced by numerous studies and reviews. This indicates the potential clinical utility of EpCAM as a diagnostic and therapeutic target for cancer treatment.
Other names	The Epithelial Cell Adhesion Molecule, also known as EpCAM or CD326, is a glycoprotein located on the surface of epithelial cells. It has numerous alternative names, including Adenocarcinoma-associated antigen and Tumor-associated calcium signal transducer 1. EpCAM is involved in cell adhesion, migration, proliferation, and differentiation. It is expressed in various epithelia, such as the gastrointestinal tract, liver, and breast, and is also present in circulating tumor cells. Studies have shown that abnormal expression of EpCAM is associated with cancer development and progression, making it a target for cancer therapy. EpCAM is therefore a valuable biomarker for cancer diagnosis and treatment.
Source	Rabbit
Specificity	The TACSTD1 Antibody is capable of identifying the complete amount of TACSTD1 that occurs naturally within an organism. You can create similar content by rephrasing the original information, without relying on ChapGPT to generate dialogue. Instead, use language modeling to develop a distinct way of communicating the content.
Species Reactivity	Human;Mouse;Rat
Antigen	TACSTD1
Application	WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TACSTD1.
MW	35kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Tissue specificity	Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Posttranslational modification	Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P16422