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Rabbit Anti-SPTAN1 Polyclonal Antibody#abs137324

Description

Catalog-specification	Delivery time	USD price
abs137324-100ug	1-2 Weeks	301.0
abs137324-50ug	1-2 Weeks	201.0

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Overview
catalog	abs137324
Other names	Alpha-II spectrin, also known as Alpha II Spectrin or Spectrin alpha chain, is a protein that plays a crucial role in the brain. It is encoded by the SPTAN1 gene and is involved in various neurological disorders, including Epileptic Encephalopathy, type 5 (EIEE5). Alpha-II spectrin is also referred to as FLJ17738, FLJ44613, Fodrin alpha chain, NEAS, non-erythroid alpha chain, SPECA, Spectrin alpha chain brain, Spectrin alpha non-erythrocytic 1, Spectrin non-erythroid alpha chain, and Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin). An alternative name for Alpha-II spectrin is SPTA2 or Spna2. This protein has a significant impact on neuronal function and is essential for maintaining the structural integrity of the brain cells.
Source	Rabbit
Specificity	The detection of endogenous levels of total SPTAN1 is achieved using the SPTAN1 Antibody. This antibody specifically targets and identifies the complete amount of SPTAN1 present in a sample. By detecting the endogenous levels, it allows for a comprehensive understanding of the expression and distribution of SPTAN1 within the biological system under investigation.
Species Reactivity	Human
Predictive reaction species	Rabbit;Bovine;Dog;Horse;
Antigen	SPTAN1
Application	The recommended dilution for western blot is 1:1000-3000, while for immunofluorescence (IF) and immunocytochemistry (ICC) it is 1:100-1:500. For ELISA using a peptide, the suggested dilution ranges from 1:20000-1:40000. It is important to follow these dilution guidelines to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human SPTAN1.
MW	285 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, the product should be stored at a temperature of -20 °C for a period of one year. It is important to avoid subjecting it to repeated freeze and thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Posttranslational modification	Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;
UniPort	Q13813