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Rabbit Anti-SOX17 Polyclonal Antibody#abs138610

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Description

Catalog-specification	Delivery time	USD price
abs138610-100ug	1-2 Weeks	301.0
abs138610-50ug	1-2 Weeks	201.0

Overview
catalog	abs138610
Other names	SOX17 (also known as FLJ22252 or SOX17_HUMAN) is a vital transcription factor responsible for regulating gene expression. It belongs to the SRY (sex determining region Y) box family and specifically the subgroup containing SRY box 17. This transcription factor, named SRY related HMG box transcription factor SOX17, plays a crucial role in various biological processes. One significant function of SOX17 is its involvement in embryonic development, particularly in the formation of the cardiovascular and endodermal systems. It acts as a key regulator during specification and differentiation of these tissues. Additionally, SOX17 has been associated with the regulation of several genes involved in stem cell pluripotency and self-renewal, making it crucial for maintaining cellular identity and tissue homeostasis. SOX17 is also implicated in various disease conditions. Mutations in the SOX17 gene have been linked to the development of certain congenital abnormalities, including vertebral defects and anal atresia. Furthermore, altered expression levels of SOX17 have been observed in several types of cancer, indicating its potential role as a tumor suppressor or oncogene, depending on the context. In conclusion, SOX17 is a transcription factor that plays diverse roles in embryonic development, stem cell regulation, and disease pathogenesis. Its intricate involvement in various biological processes highlights its significance in maintaining cellular identity and tissue integrity. Through further research, unlocking the precise mechanisms underlying SOX17's functions may provide valuable insights into both developmental biology and disease therapeutics.
Source	Rabbit
Specificity	The detection of endogenous levels of total SOX17 is facilitated by the SOX17 Antibody. By rearranging the above content, a highly similar statement is generated without altering the original text information.
Species Reactivity	Human;Mouse
Antigen	SOX17
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human SOX17.
MW	47 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. It is important to refrain from repeatedly subjecting the product to freeze/thaw cycles, which can result in quality degradation.
Storage buffer	This is a description for Rabbit IgG stored in a solution of phosphate buffered saline at a pH of 7.4, 150mM NaCl, and 0.02% sodium azide. This solution also has 50% glycerol and it is advised to store it at a temperature of -20°C. You can keep the Rabbit IgG in this solution for up to 12 months from the date that you receive it.
Target
Background	Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity).
Tissue specificity	Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum.
Celluar localization	Nucleus;
UniPort	Q9H6I2