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Rabbit Anti-SNX3 Polyclonal Antibody#abs134839

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Description

Catalog-specification	Delivery time	USD price
abs134839-100ug	1-2 Weeks	301.0
abs134839-50ug	1-2 Weeks	201.0

Overview
catalog	abs134839
Other names	SNX3, also known as sorting nexin 3, is a protein that plays a crucial role in cellular sorting and trafficking. It is encoded by various genes such as Grd19, MCOPS8, MGC151262, MGC151266, MGC17570, OTTHUMP00000016941, OTTHUMP00000046475, and OTTHUMP00000046476. Protein SDP3 is a synonym used for sorting nexin 3, which can also be referred to as sorting nexin 3A. SNX3 is a highly conserved protein present in most eukaryotic organisms. The function of SNX3 is to bind to specific cellular membranes and sort cargo between them. It has been shown to regulate the trafficking of various proteins, including receptors, ion channels, and enzymes. Overall, SNX3 is a crucial protein involved in cell biology and is important for maintaining proper cellular function and homeostasis.
Source	Rabbit
Specificity	The total SNX3 endogenous levels are detected by the SNX3 Antibody. The above information can be rearranged to generate highly similar content.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Horse;Bovine;
Antigen	SNX3
Application	1:5001:1000，/1:1001:500。（ELISA），1:200001:40000。，ChapGPT，。
Immunogen	A synthesized peptide.
MW	18 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	This product is Rabbit IgG that comes in a solution containing phosphate buffered saline and 150mM NaCl, with a pH of 7.4. It also includes 0.02% sodium azide and 50% glycerol for stability, and is recommended to be stored at -20 °C. The product is expected to remain stable for 12 months, starting from the date of receipt.
Target
Background	Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2) (By similarity). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC/VPS). May in part act as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway (PubMed:21725319, PubMed:24344282). Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes (PubMed:23237080). Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor TFRC presumably by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex (By similarity). In the case of Salmonella enterica infection plays arole in maturation of the Salmonella-containing vacuole (SCV) and promotes recruitment of LAMP1 to SCVs (PubMed:20482551).
Posttranslational modification	Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10 (By similarity).
Celluar localization	Cytosol;Endosome;Extracellular region or secreted;
UniPort	O60493