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Rabbit Anti-SEMA4D Polyclonal Antibody#abs137535

Please be advised that the mentioned price is just for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis SEMA4D using K562 whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs137535-100ug	1-2 Weeks	301.0
abs137535-50ug	1-2 Weeks	201.0

Please be advised that the mentioned price is just for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs137535
Other names	CD100 antigen, also known as semaphorin 4D (Sema4D), is a protein that belongs to the semaphorin family and is involved in cell signaling. Sema4D is known to be involved in various physiological processes, including immune responses, angiogenesis, and neuronal development. It comprises a sema domain, an immunoglobulin domain, a transmembrane domain, and a short cytoplasmic domain. The protein is encoded by the CD100 gene and is expressed in a wide variety of tissues. CD100 antigen has also been implicated in the progression of certain diseases, such as cancer, cardiovascular disease, and autoimmune disorders. It is worth noting that semaphorins are crucial molecular cues that regulate cell migration, differentiation, and survival during development and disease. Semaphorin 4D binds to its receptor, plexin-B1, initiating a downstream signaling cascade that influences a wide range of biological processes. Overall, CD100 antigen/Sema4D represents an intriguing molecule with vast physiological and pathological implications.
Source	Rabbit
Specificity	The endogenous levels of total SEMA4D can be accurately identified using the SEMA4D Antibody. In order to provide a highly similar content based on the original text information, the rearranged version could be: The SEMA4D Antibody is capable of detecting the total SEMA4D present in the body at its natural levels.
Species Reactivity	Human
Predictive reaction species	Rabbit
Antigen	SEMA4D
Application	The recommended dilutions for WB are 1:1000-3000, for IHC it is 1:200, and for ELISA (peptide) it ranges from 1:20000-1:40000. Please note that the generated content should be different from the original text, not following the conversation flow of ChapGPT.
Immunogen	A synthesized peptide derived from human SEMA4D.
MW	96 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated cycles of freezing and thawing. Taking these precautions will help ensure the product's longevity and effectiveness.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Tissue specificity	Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q92854