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Rabbit Anti-SEMA3A Polyclonal Antibody#abs138129

Description

Catalog-specification	Delivery time	USD price
abs138129-100ug	1-2 Weeks	301.0
abs138129-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138129
Other names	Semaphorin 3A, also known as Coll 1, Collapsin 1, HH16, Hsema I, Hsema III, or Sema III, is a protein that belongs to the semaphorin family. It contains a sema domain, immunoglobulin domain (Ig), short basic domain, and is secreted. The precursor form of Semaphorin 3A is involved in various biological processes, including growth cone guidance and immune response regulation. Moreover, Semaphorin 3A plays a significant role in neural development by guiding axon growth and patterning during embryogenesis. It is also involved in angiogenesis inhibition and tumor progression regulation. Additionally, Semaphorin 3A has been implicated in immune cell regulation, specifically by promoting the formation of immunosuppressive T regulatory cells and inhibiting pro-inflammatory responses. Furthermore, Semaphorin 3A is widely expressed in numerous tissues, such as the nervous system, lung, heart, and kidney. Its signaling is mainly mediated through binding to neuropilin and plexin receptors, which subsequently activate downstream signaling pathways to elicit cellular responses. In summary, Semaphorin 3A is a multifunctional protein that plays a crucial role in various physiological and pathological processes. Its diverse functions make it an attractive target for therapeutic interventions in conditions such as cancer, inflammation, and neurodevelopmental disorders.
Source	Rabbit
Specificity	Total levels of endogenous SEMA3A can be detected using the SEMA3A Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Chicken;Sheep;Dog;Horse;Bovine;
Antigen	SEMA3A
Application	The dilution ranges for WB, IHC, and ELISA are as follows: WB should be diluted at a ratio of 1:1000-3000, IHC at a ratio of 1:200, and ELISA (peptide) at a ratio of 1:20000-1:40000. Make sure to adjust the dilution accordingly based on the original instructions provided.
Immunogen	A synthesized peptide derived from human SEMA3A.
MW	88 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography to achieve purification.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that the storage temperature is maintained at -20 °C for a period of one year and avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.
Celluar localization	Extracellular region or secreted;
UniPort	Q14563