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Rabbit Anti-SCML2 Polyclonal Antibody#abs139416

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Description

Catalog-specification	Delivery time	USD price
abs139416-100ug	1-2 Weeks	301.0
abs139416-50ug	1-2 Weeks	201.0

Overview
catalog	abs139416
Other names	SCML2, also known as sex comb on midleg like 2, is a protein that shares homology with the Drosophila sex comb on midleg protein. SCML2 plays a crucial role in maintaining gene expression patterns during cellular differentiation and development. It also interacts with other proteins and complexes to regulate chromatin structure and gene transcription. Mutations in SCML2 have been associated with various disorders, including cancer, developmental abnormalities, and fertility problems. Understanding the functions and mechanisms of SCML2 may provide valuable insights into the pathogenesis and treatment of these diseases.
Source	Rabbit
Specificity	The total amount of SCML2 can be measured using the SCML2 Antibody, which specifically targets endogenous SCML2 levels. Hence, this antibody is capable of detecting the natural expression of SCML2 within a sample.
Species Reactivity	Human;Mouse
Antigen	SCML2
Application	The recommended dilutions for Western blot are between 1:1000 to 1:3000, for IHC it is 1:200, and for ELISA (peptide) it is between 1:20000 to 1:40000. It is important to use the appropriate dilution for each application to ensure accurate results. Diluting the sample too much could lead to a weak signal, whereas using a higher concentration could lead to non-specific binding and background noise. Therefore, it is crucial to optimize the dilution for each specific experiment to obtain reliable and reproducible data.
Immunogen	A synthesized peptide derived from human SCML2.
MW	77 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is also important to avoid subjecting the product to repeated freeze/thaw cycles as this could be detrimental to its stability and efficacy. Take care to follow these guidelines to ensure optimal preservation of the product.
Storage buffer	This product contains rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. Please store this solution at a temperature of -20 °C for optimal stability, and it will remain viable for 12 months from the date of receipt.
Target
Background	Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).
Tissue specificity	Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.
Celluar localization	Nucleus;
UniPort	Q9UQR0