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Rabbit Anti-Sarcoglycan-beta Polyclonal Antibody#abs138125

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Description

Catalog-specification	Delivery time	USD price
abs138125-100ug	1-2 Weeks	301.0
abs138125-50ug	1-2 Weeks	201.0

Overview
catalog	abs138125
Other names	The 43 kDa dystrophin-associated glycoprotein, also known as 43DAG or A3b, is an important protein that plays a crucial role in muscular dystrophy. It is also referred to as beta-sarcoglycan or beta-SG and is encoded by the SGCB gene. Patients with mutations in the SGCB gene may suffer from limb girdle muscular dystrophy 2E (LGMD2E) in non-linked families. The dystrophin-associated glycoprotein, 43-kD is a vital component of the dystrophin-glycoprotein complex, which is responsible for maintaining the structural integrity of muscle cells. It is mainly expressed in skeletal and cardiac muscle. Multiple isoforms of beta-sarcoglycan have been identified. Studies have shown that the loss of beta-sarcoglycan function leads to a disruption of the dystrophin-glycoprotein complex, which ultimately results in muscle weakness and wasting. Therefore, it is crucial to understand the functional significance of beta-sarcoglycan in the pathogenesis of muscular dystrophy and find potential therapies. In summary, beta-sarcoglycan is an important glycoprotein associated with dystrophin that plays a vital role in maintaining the structural integrity of muscles. Its mutations can lead to LGMD2E, a form of muscular dystrophy. Therefore, further research on the functional significance of beta-sarcoglycan is essential for developing potential therapeutic strategies for muscular dystrophy.
Source	Rabbit
Specificity	Endogenous levels of total Sarcoglycan-β can be identified using the Sarcoglycan-β Antibody. It is a reliable tool for detecting this specific protein in biological samples. The antibody has been designed to recognize and bind to the target protein with high specificity. With this antibody, researchers can gain valuable insights into the expression patterns and functions of Sarcoglycan-β in various physiological and pathological conditions. The ability to detect endogenous levels of total Sarcoglycan-β makes this antibody an important tool for investigating this important protein in depth.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	Sarcoglycan-β
Application	The recommended dilutions for Western blot (WB) range from 1:1000 to 1:3000, for immunohistochemistry (IHC) it is 1:200, and for ELISA (peptide) it is between 1:20000 and 1:40000. It is important to adhere to these dilutions to obtain accurate results.
Immunogen	Sarcoglycan-βSarcoglycan-β。Sarcoglycan-β，。，。。，。，，。
MW	34 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this may compromise its integrity. Following these storage guidelines will help ensure that the product remains stable and effective over time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Tissue specificity	Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver.
Posttranslational modification	Disulfide bonds are present.
Celluar localization	Cytoskeleton;Plasma Membrane;
UniPort	Q16585