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Rabbit Anti-REN Polyclonal Antibody#abs134721

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Description

Catalog-specification	Delivery time	USD price
abs134721-50ug	1-2 Weeks	201.0
abs134721-100ug	1-2 Weeks	301.0

Overview
catalog	abs134721
Other names	Renin, also known as angiotensinogenase or angiotensin forming enzyme, is an enzyme that plays a crucial role in regulating blood pressure and fluid balance in the body. It is synthesized and secreted by the kidney and acts on angiotensinogen to cleave it into angiotensin I, which is then converted to angiotensin II by angiotensin converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor that increases blood pressure and stimulates the release of aldosterone, a hormone that promotes sodium reabsorption in the kidneys. Renin is encoded by the REN gene and exists in several isoforms, including Ren1 and Renin precursor renal. Other names for renin include HNFJ2, FLJ10761, and angiotensinogenase precursor. Understanding the role of renin is important in the diagnosis and treatment of hypertension and other cardiovascular diseases.
Source	Rabbit
Specificity	The REN Antibody has the ability to recognize the total amount of REN naturally present in the body. To be more precise, this antibody can identify endogenous levels of REN.
Species Reactivity	Human
Antigen	REN
Application	For Western blotting, the recommended dilution range is between 1:500 to 1:1000. Meanwhile, when performing immunofluorescence or immunocytochemistry, the antibody should be diluted to a concentration range of 1:100 to 1:500. Lastly, for ELISA assays using peptide antigens, it is suggested to dilute the antibody to a range of 1:20000 to 1:40000. It is important to carefully follow these dilution guidelines to ensure optimal results in your experiments.
Immunogen	A synthesized peptide.
MW	40 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To achieve a highly effective purity, this process was carefully carried out to ensure that the resulting antiserum was of top quality.
Clonality	Polyclonal Antibody
Stability & Storage	The storage temperature for one year is at -20 °C. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	This solution contains rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at -20 °C and it should remain stable for 12 months from the date of receipt.
Target
Background	Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P00797