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Rabbit Anti-RECQL4 Polyclonal Antibody#abs138777

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Description

Catalog-specification	Delivery time	USD price
abs138777-100ug	1-2 Weeks	301.0
abs138777-50ug	1-2 Weeks	201.0

Overview
catalog	abs138777
Other names	RecQ-like type 4 is a DNA helicase enzyme that relies on ATP for its function. It is also known as ATP-dependent DNA helicase Q4, DNA helicase, or simply RecQ4. This protein plays a crucial role in maintaining and repairing DNA strands. RECQL4, the gene that codes for RecQ4, is found in humans and is associated with Rothmund-Thomson syndrome (RTS), which is a rare genetic disorder characterized by skin abnormalities, skeletal issues, and an increased risk of developing certain types of cancer. RecQ4 is classified as a RecQ-like helicase due to its structural and functional similarities to other members of the RecQ family. These helicases have ATPase activity and are involved in DNA replication, recombination, and repair processes. The specific functions of RecQ4 are not fully understood, but it is thought to participate in DNA unwinding and resolution of DNA structures during replication and repair. By unwinding DNA strands, RecQ4 allows other enzymes and proteins to access and process the DNA more effectively. Mutations in the RECQL4 gene disrupt the function of RecQ4 and have been linked to Rothmund-Thomson syndrome. This syndrome is characterized by various symptoms, including premature aging, short stature, cataracts, skeletal abnormalities, and an increased risk of developing osteosarcoma, a type of bone cancer. In conclusion, ATP-dependent DNA helicase Q4, also known as RecQ4, is a crucial protein involved in DNA maintenance and repair. It belongs to the RecQ-like helicase family and is associated with Rothmund-Thomson syndrome when mutated. Further research is needed to fully understand the precise roles of RecQ4 in DNA metabolism and its implications for human health.
Source	Rabbit
Specificity	Total RECQL4 levels can be effectively detected using the RECQL4 Antibody, allowing for the measurement of endogenous RECQL4 levels.
Species Reactivity	Human
Antigen	RECQL4
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RECQL4.
MW	133 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent peptide affinity chromatography purification. To ensure high purity, this method allowed for the selective immobilization of peptides onto the solid support resin, which resulted in a highly specific and efficient purification process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is advised to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the item to repeated freeze/thaw cycles as this can have detrimental effects. Take caution in storing the product appropriately to maintain its quality and effectiveness.
Storage buffer	This product contains Rabbit IgG in a phosphate buffered saline solution with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store at a temperature of -20°C and is stable for a period of 12 months from the date of receipt. Please ensure to follow these guidelines for optimal performance and longevity of the product.
Target
Background	DNA-dependent ATPase. May modulate chromosome segregation.
Tissue specificity	Ubiquitously expressed, with highest levels in thymus and testis.
Celluar localization	Nucleus;
UniPort	O94761