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Rabbit Anti-RAB11FIP5 Polyclonal Antibody#abs139316

Please note that the price provided is only for your reference, and for detailed pricing information, we kindly advise you to reach out to our seller Vecent. Thank you. Western blot analysis RAB11FIP5 using COS7 whole cell lysates This product is for research use only, not for use in diagnostic...

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Description

Catalog-specification	Delivery time	USD price
abs139316-100ug	1-2 Weeks	301.0
abs139316-50ug	1-2 Weeks	201.0

Please note that the price provided is only for your reference, and for detailed pricing information, we kindly advise you to reach out to our seller Vecent. Thank you.

Overview
catalog	abs139316
Other names	GAF1, also known as gamma-SNAP-associated factor 1 or KIAA0857, is a phosphoprotein pp75 that interacts with the RAB11 family proteins. It is also referred to as Rab11 family-interacting protein 5 or Rab11-FIP5. Another name for GAF1 is Rab11 interacting protein or Rab11-interacting protein Rip11. Its presence has been identified in humans and is denoted by the protein code RFIP5_HUMAN. GAF1 plays a crucial role in intracellular vesicle trafficking and membrane transport. By associating with gamma-SNAP, GAF1 facilitates the targeting and fusion of vesicles with their respective target membranes. This interaction enhances the efficiency and specificity of intracellular transport processes. Phosphorylation of GAF1 regulates its activity and involvement in membrane trafficking pathways. It has been observed that GAF1 undergoes phosphorylation at specific sites, which further modulates its interaction with RAB11 and other associated proteins. This mechanism ensures tight regulation of vesicle trafficking events in different cellular contexts. The diverse names, such as GAF 1, Gaf-1, and GAF1, refer to the same protein entity and underscore the significant interest and research focused on this molecule. Understanding the functions and regulatory mechanisms of GAF1 provides valuable insights into fundamental cellular processes and their relevance in health and disease.
Source	Rabbit
Specificity	The RAB11FIP5 Antibody can identify the complete levels of RAB11FIP5 that exist within an organism. This means that it is capable of detecting the natural amounts of RAB11FIP5 that are present without adding or removing any elements.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Dog;Horse;
Antigen	RAB11FIP5
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	Human RAB11FIP5 can be utilized to synthesize a peptide through rearrangement and manipulation. The resultant synthesized peptide will closely resemble the original sequence and information of RAB11FIP5.
MW	70 kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was used to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality and effectiveness of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles. This will help to ensure the product remains stable and effective for its intended use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Tissue specificity	Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.
Posttranslational modification	Phosphorylated on serine and threonine residues. Phosphorylation at Ser-357 is PKA-dependent.
Celluar localization	Cytoskeleton;Endosome;Golgi apparatus;Mitochondrion;
UniPort	Q9BXF6