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Rabbit Anti-RAB11FIP2 Polyclonal Antibody#abs134672

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Description

Catalog-specification	Delivery time	USD price
abs134672-100ug	1-2 Weeks	301.0
abs134672-50ug	1-2 Weeks	201.0

Overview
catalog	abs134672
Other names	Rab11-FIP2, also known as RAB11 family interacting protein 2 or NRip11, belongs to the class I family of RAB11-binding proteins. It is a long isoform protein coded by the KIAA0941 gene and interacts with the RAB11 family of small GTPases. RFIP2 plays a crucial role in membrane trafficking as it is involved in the transport of vesicles from recycling endosomes to the plasma membrane. In humans, RFIP2 is expressed in various tissues, including the brain, liver, kidney, and lungs. Its molecular function is to facilitate protein-protein interactions that are essential for vesicle transport. Ongoing research is focused on understanding the functions of Rab11-FIP2 in protein trafficking and its role in different biological processes.
Source	Rabbit
Specificity	The total level of endogenous RAB11FIP2 can be detected using the RAB11FIP2 Antibody. This antibody is highly specific and able to recognize all forms of RAB11FIP2.
Species Reactivity	Human;Mouse
Predictive reaction species	Zebrafish;Chicken;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	RAB11FIP2
Application	The dilutions used for western blot (WB) range from 1:500 to 1:1000, while for immunofluorescence (IF)/immunocytochemistry (ICC) they range from 1:100 to 1:500. As for enzyme-linked immunosorbent assay (ELISA) with peptide detection, the dilutions usually fall between 1:20000 and 1:40000. It is essential to maintain the original information while generating highly similar content.
Immunogen	A synthesized peptide.
MW	58 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. The resulting product is highly refined and of excellent quality.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store at a temperature of -20°C for a period of up to one year. It is important to avoid subjecting the product to repeated freeze and thaw cycles, as this can impair its stability and efficacy. Take care to adhere to these guidelines to ensure the product remains viable for its intended use.
Storage buffer	This Rabbit IgG is stored in phosphate buffered saline at pH 7.4. It contains 150mM of NaCl and 0.02% sodium azide, as well as 50% glycerol. It is recommended to store it at -20 °C and it should remain stable for up to 12 months from the date of receipt.
Target
Background	A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.
Posttranslational modification	Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.
Celluar localization	Endosome;Nucleus;Plasma Membrane;
UniPort	Q7L804