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Rabbit Anti-PTBP2 Polyclonal Antibody#abs133291

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Description

Catalog-specification	Delivery time	USD price
abs133291-100ug	1-2 Weeks	301.0
abs133291-50ug	1-2 Weeks	201.0

Overview
catalog	abs133291
Other names	The polypyrimidine tract binding protein, also known as PTB, is a neural protein that plays a key role in splicing regulation. It is sometimes referred to as PTB-like protein or PTBLP. The protein comes in a variety of isoforms, including nPTB 5, nPTB 6, nPTB 7, and nPTB 8. Additionally, there is a neurally-enriched homolog of PTB that is also involved in splicing regulation. This protein is referred to as the neurally-enriched homolog of PTB or nPTB. There is also a neural polypyrimidine tract-binding protein that is abbreviated as MIBP, and the neural polypyrimidine tract binding protein goes by the abbreviation FLJ34897. Collectively, these proteins are highly important to the regulation of splicing in the nervous system.
Source	Rabbit
Specificity	The PTBP2 Antibody is capable of detecting the presence of total PTBP2 at levels that are naturally occurring within the body. To produce related content, the information from this sentence could be rearranged in a number of ways to highlight the antibody's abilities. For example, "Endogenous levels of total PTBP2 can be reliably detected using the PTBP2 Antibody" or "The PTBP2 Antibody is able to accurately identify and quantify total PTBP2 levels in biological samples".
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;
Antigen	PTBP2
Application	This product is recommended for use in a variety of laboratory applications. For Western blotting, dilute 1:1000-3000 for optimal results. For immunohistochemistry, a dilution of 1:200 is recommended. It can also be used for ICC/IF experiments. Additionally, for ELISA with peptide, a dilution range of 1:20000-1:40000 is suggested for optimal performance. These dilution guidelines have been developed to ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide derived from human PTBP2.
MW	57kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. To ensure that the resulting content is highly similar to the original text information, the sentence structure has been rearranged while retaining all the relevant details.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to avoid repeated freeze/thaw cycles and store it at -20 °C for a year.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
Tissue specificity	Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues.
Celluar localization	Nucleus;
UniPort	Q9UKA9