Rabbit Anti-PSMD2 Polyclonal Antibody #abs130525

abs130525-50ug

1-2 Weeks

201

abs130525-100ug

1-2 Weeks

301

Description

The 26 proteasome requires regulatory subunits like PSMD2 to function properly in the ATP-dependent breakdown of ubiquitinated proteins. PSMD2 serves as a crucial component in the degradation of targeted proteins and without it, this process is compromised. As a regulatory subunit, PSMD2 plays an essential role in ensuring that the proteasome complex remains stable and efficient in processing the numerous targets that require degradation. Understanding the function and regulation of subunits such as PSMD2 is critical in understanding the overall mechanism of protein degradation.

Other names

Proteasome 26S subunit non-ATPase regulatory subunit 2 (PSMD2), also known as 26S proteasome regulatory subunit RPN1 or 26S proteasome regulatory subunit S2, is a protein encoded by the PSMD2 gene in humans. It is also referred to as p97 or 55.11 protein. Other alternative names include MGC14274, Protein 55.11, Psmd2, Rpn1, S2, TNFR associated protein 2, TRAP2, and Tumor necrosis factor receptor associated protein 2.
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Source

Rabbit

Specificity

PSMD2 Antibody detects endogenous levels of PSMD2

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human PSMD2

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

For a period of one year, it is recommended to store this item at a temperature of -20 °C. It is important to avoid any repeated cycles of freezing and thawing. Ensuring that these guidelines are followed will help to maintain the integrity and quality of the product over time.

Storage buffer

This product contains rabbit IgG in a solution of phosphate buffered saline, with a pH of 7.4. The solution also includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol for stabilization. To ensure the longevity of the product, it should be stored at a temperature of -20 °C. The solution is stable for up to 12 months from the date of receipt. Overall, this high-quality solution provides users with a reliable source of rabbit IgG for various research applications.

Target

Background

The 26S proteasome is a crucial component of the cellular machinery responsible for breaking down proteins tagged with ubiquitin in an ATP-dependent manner. By eliminating proteins that are misfolded, damaged, or no longer needed, this multiprotein complex is vital in maintaining protein homeostasis. Its involvement in various cellular processes such as cell cycle progression, apoptosis, and DNA damage repair further underscores its significance. In summary, the proteasome ensures the removal of detrimental proteins, safeguarding cellular functions and overall wellbeing.

Tissue specificity

The presence of this particular substance can be confirmed in various vital organs and tissues throughout the body, including skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.

Celluar localization

Cytosol;Extracellular region or secreted;Nucleus;

UniPort

Q13200