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Rabbit Anti-PSMA4 Polyclonal Antibody#abs136496

Description

Catalog-specification	Delivery time	USD price
abs136496-100ug	1-2 Weeks	301.0
abs136496-50ug	1-2 Weeks	201.0

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Overview
catalog	abs136496
Description	The 20S core structure of the proteasome is a well-organized, ring-shaped proteinase complex. It consists of four rings comprised of a total of 28 subunits, each of which is unique. The two alpha subunits rings contain seven subunits each, while the two beta subunit rings also consist of seven subunits. This vital cellular component, the proteasome, is widely distributed throughout eukaryotic cells in high concentrations. It plays a role in cleaving peptides through a process that relies on ATP and ubiquitin, following a non-lysosomal pathway. Among the various functions performed by modified proteasomes, the immunoproteasome is particularly essential. It is involved in processing class I MHC peptides. The gene responsible for encoding a specific 20S core alpha subunit of the peptidase T1A family is highly relevant in this context. It is worth noting that this gene exhibits alternative splicing, resulting in three different transcript variants that produce distinct isoforms. This genetic diversity adds complexity and versatility to the functioning of the proteasome system.
Other names	The human proteasome component C9, also known as multicatalytic endopeptidase complex subunit C9, macropain subunit C9, or proteasome subunit alpha type 4, is a vital molecule involved in protein degradation. It is a member of the proteasome subunit alpha type-4 family and is encoded by the HC9 gene in humans. Other aliases attributed to this molecule include HsT17706, MGC111191, MGC12467, MGC24813, PSA4_HUMAN, PSC9, and PSMA 4. The alpha 4 subunit of the proteasome is critical in the complete assembly of the proteasome complex, which breaks down damaged and unwanted proteins. The proteasome is essential for the regulation of protein turnover, cell cycle control, signal transduction, and antigen processing. The alpha 4 subunit specifically plays a role in the activation of the enzymatic activity of the proteasome. Research has shown that the expression of the C9 gene is upregulated in certain cancer cells and is associated with increased cell proliferation and decreased apoptosis. Additionally, mutations in the C9 gene have been linked to various genetic diseases, including Parkinson's disease and Alzheimer's disease. Overall, the proteasome subunit alpha type 4, or C9, plays a critical role in cellular homeostasis and has significant implications in diseases such as cancer and neurodegenerative disorders. Further research is necessary to understand the full extent of its functions and potential therapeutic targets.
Source	Rabbit
Specificity	The PSMA4 Antibody is capable of detecting the total PSMA4 levels that are naturally present within the body.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Zebrafish;Chicken;Pig;Sheep;Horse;Bovine;Rabbit;
Antigen	PSMA4
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB should be diluted from 1:500 to 1:2000, IHC should be diluted from 1:50 to 1:200, and ELISA (peptide) should be diluted from 1:20000 to 1:40000. These dilutions are recommended for efficient and accurate detection of the target proteins. It is important to follow the suggested dilution ratios to obtain reliable results in WB, IHC, and ELISA experiments.
Immunogen	A synthesized peptide derived from human PSMA4.
MW	29kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Tissue specificity	Down-regulated by antioxidants BO-653 and probucol.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	P25789