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Rabbit Anti-PRLHR Polyclonal Antibody#abs131307

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Description

Catalog-specification	Delivery time	USD price
abs131307-50ug	1-2 Weeks	201.0
abs131307-100ug	1-2 Weeks	301.0

Overview
catalog	abs131307
Description	The prolactin-releasing peptide (PrRP) receptor plays a crucial role in various physiological processes such as lactation, food intake regulation, and processing of pain signals. It is involved in the intricate mechanisms of milk production, controlling appetite, and the perception of pain.
Other names	The G protein-coupled receptor 10, also known as GPR10, GR3, hGR3, or uhr-1, is a protein that plays a key role in cellular signaling. This receptor is encoded by two genes, MGC126539 and MGC126541. In humans, it is commonly referred to as Prolactin-releasing hormone receptor (PRLHR) or Prolactin-releasing peptide receptor (PrRPR). The PRLHR is primarily responsible for regulating the secretion of prolactin, which is an important hormone involved in lactation and fertility. PrRP, on the other hand, is a neuropeptide that regulates many different physiological processes, including food intake, energy metabolism, and stress responses. The structure of the PRLHR is composed of seven transmembrane domains that are characteristic of G protein-coupled receptors. When a ligand binds to the receptor, it triggers a conformational change that activates downstream signaling pathways. These pathways ultimately lead to the release of prolactin or other physiological responses. Understanding the function of the PRLHR is crucial for developing treatments for diseases related to hormone imbalances, such as infertility, lactation disorders, and cancer. Further research is needed to fully elucidate the complex mechanisms of this receptor and its role in human health.
Source	Rabbit
Specificity	The total PRLHR levels can be detected by the PRLHR Antibody, which specifically identifies endogenous levels of the protein. By rearranging the given content, the following highly similar content is generated: The PRLHR Antibody is capable of detecting the total levels of PRLHR in the body. It is designed to target the endogenous levels of this protein and provide accurate identification.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	PRLHR
Application	For Western blotting, dilute the antibody at a ratio of 1:500 to 1:2000. When it comes to immunofluorescence or immunocytochemistry, the antibody should be diluted at a ratio of 1:100 to 1:500. For ELISA using peptide antigens, dilute the antibody at a ratio of 1:20000 to 1:40000. By following these dilution guidelines, you can ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide derived from human PRLHR.
MW	41 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was refined through peptide affinity chromatography. This process ensures a highly purified product that can be used effectively in various applications.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing.
Tissue specificity	Only detected in the pituitary gland and in all cell types of pituitary adenomas.
Celluar localization	Plasma Membrane;
UniPort	P49683