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Rabbit Anti-PNPLA6 Polyclonal Antibody#abs134545

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Description

Catalog-specification	Delivery time	USD price
abs134545-100ug	1-2 Weeks	301.0
abs134545-50ug	1-2 Weeks	201.0

Overview
catalog	abs134545
Other names	Neuropathy target esterase (NTEMND), also known as Patatin-like phospholipase domain-containing protein 6 (PLPL6_HUMAN) or Patatin like phospholipase domain containing 6 (Pnpla6), is a protein that plays a crucial role in various cellular processes. It is encoded by the gene SPG39 and is associated with conditions such as hereditary spastic paraplegia (sws) and neuropathy. NTEMND belongs to the patatin-like phospholipase family and contains a domain that is commonly found in proteins involved in lipid metabolism. This suggests that NTEMND may have a role in lipid processing and signaling pathways within cells. One of the main functions of NTEMND is its involvement in the maintenance of neuronal health. It is particularly important in preventing the development of neurodegenerative diseases such as hereditary spastic paraplegia. Mutations in the gene encoding NTEMND can lead to dysfunction of the protein, causing impaired lipid metabolism and ultimately leading to the degeneration of nerve fibers. NTEMND has been found to be present in various tissues, with higher expression levels observed in the brain, spinal cord, and peripheral nerves. Its expression pattern suggests that it plays a crucial role in the normal functioning of the nervous system. In conclusion, NTEMND is an essential protein involved in lipid metabolism and the maintenance of neuronal health. Its dysfunction can lead to neurodegenerative diseases such as hereditary spastic paraplegia. Further research on this protein may provide valuable insights into the treatment and prevention of such conditions.
Source	Rabbit
Specificity	The PNPLA6 Antibody is able to detect the total amount of endogenous PNPLA6 present in the sample under observation. The detected levels of PNPLA6 are representative of the total amount of PNPLA6 present in the sample being analyzed.
Species Reactivity	Human;Mouse
Antigen	PNPLA6
Application	For Western blotting, a dilution of 1:500 to 1:1000 is recommended. For immunofluorescence and immunocytochemistry, a dilution of 1:100 to 1:500 is ideal. For ELISA using peptide substrates, a dilution of 1:20000 to 1:40000 is recommended for optimal results. It is important to carefully follow the recommended dilution guidelines in order to achieve accurate and reliable results in your experiments. Dilution factors that are too high or too low can result in weak or non-specific staining, which can compromise the interpretation of your data.
Immunogen	A synthesized peptide.
MW	150 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. A highly refined product was achieved through this process.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal quality, it is recommended to keep the product at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this can negatively impact its efficacy and overall effectiveness. By following these storage instructions, you can ensure that the product remains stable and reliable for its intended use.
Storage buffer	The Rabbit IgG is kept in phosphate-buffered saline with a pH of 7.4, 150mM of NaCl, and 0.02% of sodium azide. Additionally, the solution includes 50% of glycerol and must be stored at -20°C. Its stability lasts for 12 months following the date of receipt. To ensure the original text information is not copied, the generated content is based on rearranging the given text.
Target
Background	Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Tissue specificity	Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
Posttranslational modification	Glycosylated.
Celluar localization	Endoplasmic reticulum;
UniPort	Q8IY17