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Rabbit Anti-PIP5K Polyclonal Antibody#abs138227

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Description

Catalog-specification	Delivery time	USD price
abs138227-100ug	1-2 Weeks	301.0
abs138227-50ug	1-2 Weeks	201.0

Overview
catalog	abs138227
Other names	Phosphatidylinositol 3 phosphate 5 kinase, also known as PIKfyve or FYVE finger-containing phosphoinositide kinase, is an enzyme involved in the regulation of cellular processes. It plays a crucial role in the conversion of phosphatidylinositol 3 phosphate (PI3P) to phosphatidylinositol 3,5 bisphosphate (PI(3,5)P2) by phosphorylating the 5-position of PI3P. PIKfyve is a homolog of FAB1, a protein found in Saccharomyces cerevisiae. It is encoded by the KIAA0981 gene and is also known by other names such as FYV1_HUMAN, CFD (epididymis luminal protein 37), and p235. Its function is mediated by a FYVE finger domain, which enables PIKfyve to specifically bind to phosphatidylinositol 3-phosphate in cellular membranes. The activity of PIKfyve is critical for various cellular processes, including endocytic trafficking, vesicle fusion, membrane dynamics, and ion transport. It is also involved in the regulation of cellular homeostasis and signaling pathways. Dysregulation of PIKfyve has been associated with several diseases, including neurodegenerative disorders, metabolic disorders, and certain types of cancer. In conclusion, PIKfyve is a key enzyme that plays a vital role in cellular processes by catalyzing the production of PI(3,5)P2. Its diverse functions and importance in various physiological and pathological conditions make it an attractive target for therapeutic interventions.
Source	Rabbit
Specificity	The total PIP5K levels present in the body can be detected using the PIP5K Antibody. This antibody is effective in identifying the endogenous levels of PIP5K protein present in the body. To generate similar content about this, one can rephrase the information by stating that the PIP5K Antibody has the ability to recognize the overall PIP5K levels that are naturally occurring in the body.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	PIP5K
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human PIP5K.
MW	237 kDa
Properties
Concentration	1mg/ml
purification	We employed SulfoLink™ Coupling Resin for peptide affinity chromatography to achieve purification of the antiserum. This process led to the efficient purification of the antiserum based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.
Posttranslational modification	Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.
Celluar localization	Cytosol;Endosome;Golgi apparatus;
UniPort	Q9Y2I7