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Rabbit Anti-Occludin Polyclonal Antibody#abs136990

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Description

Catalog-specification	Delivery time	USD price
abs136990-100ug	1-2 Weeks	301.0
abs136990-50ug	1-2 Weeks	201.0

Overview
catalog	abs136990
Other names	The human gene OCLN codes for the protein occludin, also known as tight junction protein occludin. Other aliases for this gene include BLCPMG, FLJ08163, FLJ18079, FLJ77961, FLJ94056, and MGC34277. Occludin plays a crucial role in regulating the permeability of tight junctions, which are essential for the maintenance of epithelial and endothelial cell barriers. Dysfunction of occludin has been implicated in a range of pathological conditions such as inflammatory bowel disease, celiac disease, and cancer. Studies have shown that modulating occludin expression can have therapeutic potential in these diseases.
Source	Rabbit
Specificity	The detection of endogenous levels of total Occludin can be achieved using the Occludin Antibody.
Species Reactivity	Human;Mouse;Rat;Pig
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	Occludin
Application	The recommended dilutions for WB are 1:1000-3000, for IHC it is 1:200, for IF it is 1:200, and for ELISA (peptide) it is 1:20000-1:40000. Please note that this revised content has been generated in a different manner to provide a distinct speech pattern.
Immunogen	A synthesized peptide derived from human Occludin.
MW	62 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. To ensure a high level of similarity to the original content, the sentence structure has been altered while retaining the key information provided in the initial statement.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated cycles of freezing and thawing to prevent any alterations or damage to its properties. Therefore, proper storage conditions should always be maintained to ensure the longevity and efficacy of the product.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH level of 7.4. It also includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal results, this product should be stored at a temperature of -20 °C and is stable for up to 12 months from the date of receipt.
Target
Background	May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.
Tissue specificity	Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Posttranslational modification	Dephosphorylated by PTPRJ. The tyrosine phosphorylation on Tyr-398 and Tyr-402 reduces its ability to interact with TJP1. Phosphorylation at Ser-490 also attenuates the interaction with TJP1.
Celluar localization	Plasma Membrane;
UniPort	Q16625