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Rabbit Anti-APPL1 Polyclonal Antibody#abs141062

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Description

Catalog-specification	Delivery time	USD price
abs141062-100ug	1-2 Weeks	301.0
abs141062-50ug	1-2 Weeks	201.0

Overview
catalog	abs141062
Other names	APPL1, also known as Adaptor Protein Containing pH Domain, is a signaling adaptor protein that contains a PH domain, a PTB domain, and a leucine zipper motif. It interacts with AKT2 and DCC, and is also known as AKT2 INTERACTOR and DCC-interacting protein 13-alpha. Another name for APPL1 is Dip13-alpha, or DIP 13 alpha. It is encoded by the KIAA1428 gene and plays important roles in cellular signaling and regulation. APPL1 is a versatile protein that serves as a platform for the assembly of protein complexes involved in various signaling pathways, and its dysregulation has been implicated in several diseases.
Source	Rabbit
Specificity	The APPL1 Antibody has the ability to identify total APPL1 present in the body. This detection relies on the recognition of endogenous levels of the protein.
Species Reactivity	Human;Mouse
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	APPL1
Application	ELISA (peptide) has a recommended dilution range of 1:20000-1:40000, while WB is typically diluted at 1:500~1:1000. For IF/ICC, a dilution of 1:100-1:500 is commonly advised. It is important to note that these dilution ranges are provided based on the original text information.
Immunogen	A synthesized peptide.
MW	80 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for a period of one year. It is important to note that repeated cycles of freeze/thaw should be avoided at all costs. By adhering to these guidelines, you can be assured that the product will remain in optimal condition for an extended period of time.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. Involved in the regulation of the insulin receptor signaling pathway.
Tissue specificity	High levels in heart, ovary, pancreas and skeletal muscle.
Posttranslational modification	Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.
Celluar localization	Cytosol;Endosome;Extracellular region or secreted;Nucleus;
UniPort	Q9UKG1