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Rabbit Anti-NRG4 Polyclonal Antibody#abs136566

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Description

Catalog-specification	Delivery time	USD price
abs136566-100ug	1-2 Weeks	301.0
abs136566-50ug	1-2 Weeks	201.0

Overview
catalog	abs136566
Description	NRG4, along with other neuregulins, plays a crucial role in activating type-1 growth factor receptors (such as EGFR; MIM 131550) for initiating cell-to-cell signaling through the process of tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]). By rearranging the provided information, a highly similar content can be generated. Please note that the generated content may not be an accurate reflection of the original text.
Other names	Pro-neuregulin-4 (NRG4), also known as Heregulin 4 or Neuregulin-4, is a protein encoded by the DKFZp779N0541 and DKFZp779N1944 genes. It is a membrane-bound isoform of NRG4 and is also referred to as NRG4_HUMAN. This protein plays a crucial role in various biological processes. NRG4 belongs to the neuregulin family and is involved in cell growth, proliferation, and differentiation. It acts as a signaling molecule and interacts with specific receptors on the cell surface. NRG4 has been found to be expressed in various tissues, including the heart, skeletal muscle, and brain. The function of NRG4 is not fully understood, but it is believed to play important roles in cardiovascular development and maintenance of muscle tissue. Studies have shown that NRG4 may be involved in the regulation of glucose and lipid metabolism, suggesting its potential therapeutic relevance in metabolic disorders such as obesity and diabetes. Overall, NRG4 is an important protein that is involved in various physiological processes. Further research is needed to fully understand its function and potential clinical applications.
Source	Rabbit
Specificity	The total NRG4 levels can be detected using the NRG4 Antibody, which specifically targets the endogenous levels of NRG4. Reconfiguring the information, it can be stated as follows: The NRG4 Antibody is capable of effectively identifying the total NRG4 levels present in the body, allowing researchers to accurately analyze the endogenous levels of NRG4.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig
Antigen	NRG4
Application	Here are the rearranged versions of the given content: 1. The dilution range for western blot is 1:500 to 1:2000. For immunohistochemistry, it is 1:50 to 1:100. Lastly, the dilution range for ELISA with peptide is 1:20,000 to 1:40,000. 2. When performing western blot, the recommended dilution range is 1:500 to 1:2000. For immunohistochemistry, the dilution range is 1:50 to 1:100. If you're using ELISA with a peptide, the suggested dilution range is 1:20,000 to 1:40,000. 3. If you're planning to conduct western blot, make sure to dilute the samples within the range of 1:500 to 1:2000. Immunohistochemistry requires a dilution range of 1:50 to 1:100. And if you're using ELISA with a peptide, dilute it in the range of 1:20,000 to 1:40,000. 4. Remember to dilute your samples properly for western blot, ranging from 1:500 to 1:2000. When performing immunohistochemistry, the recommended dilution range is 1:50 to 1:100. For ELISA using a peptide, dilute within the range of 1:20,000 to 1:40,000. 5. The optimal dilution range for western blot analysis is 1:500 to 1:2000. When conducting immunohistochemistry, dilute your samples within the range of 1:50 to 1:100. And if you're using ELISA with a peptide, make sure to dilute it in the range of 1:20,000 to 1:40,000.
Immunogen	A synthesized peptide derived from human NRG4.
MW	12kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the storage temperature remains at -20 °C throughout one year in order to maintain the quality of the product. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can negatively impact its integrity.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
Posttranslational modification	Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.Extensive glycosylation precedes the proteolytic cleavage.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q8WWG1