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Rabbit Anti-CCL28 Polyclonal Antibody#abs136565

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Description

Catalog-specification	Delivery time	USD price
abs136565-100ug	1-2 Weeks	301.0
abs136565-50ug	1-2 Weeks	201.0

Overview
catalog	abs136565
Description	This particular gene is a member of the small cytokine CC family and is known to be involved in immunoregulatory and inflammatory processes. CC cytokines, which are characterized by two adjacent cysteines, are a subtype of cytokine proteins that are secreted. This gene encodes a cytokine that has the ability to elicit chemotaxis in eosinophils and resting CD4 or CD8 T cells. Additionally, the product of this gene can bind to chemokine receptors CCR3 and CCR10. It is thought that this chemokine may play an important role in the functioning of various extracutaneous epithelial tissues, including multiple mucosal organs.
Other names	Chemokine (C-C motif) ligand 28, also known as CCL28 or Mucosae-associated epithelial chemokine, is a protein encoded by the CCL28 gene. It is also referred to as CCK1 or SCYA28. CCL28 is involved in immune responses and plays a role in recruiting certain immune cells to mucosal tissues. It is produced by epithelial cells in various mucosal tissues, including the respiratory and digestive tracts. CCL28 binds to a receptor called CCR10, which is expressed by certain immune cells, leading to their migration towards the mucosal tissues. This chemokine is important in maintaining immune homeostasis and may have implications in diseases related to mucosal inflammation. Further research on CCL28 and its functions could provide valuable insights into the development of therapeutic strategies for such conditions.
Source	Rabbit
Specificity	The CCL28 Antibody is capable of detecting the complete amount of endogenous CCL28 levels in samples. This means that the antibody is able to identify all forms of CCL28 molecules present in the sample, both specific and non-specific. Hence, it is a highly reliable tool for researchers who wish to study the role and expression of CCL28 in biological systems.
Species Reactivity	Human;Mouse;Rat
Antigen	CCL28
Application	The recommended dilution for WB is between 1:500 to 1:2000 while for IHC, it is between 1:50 to 1:200. Similarly, for ELISA (peptide), the suggested dilution is between 1:20000 to 1:40000. These dilution ratios are important in achieving optimal results in your experiments. It is essential to follow these recommendations to ensure reproducibility and accuracy of your data.
Immunogen	A synthesized peptide derived from human CCL28.
MW	14kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
Tissue specificity	Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin.
Celluar localization	Extracellular region or secreted;
UniPort	Q9NRJ3