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Rabbit Anti-MNAT1 Polyclonal Antibody#abs136210

Description

Catalog-specification	Delivery time	USD price
abs136210-100ug	1-2 Weeks	301.0
abs136210-50ug	1-2 Weeks	201.0

Please note that the price provided is for reference purposes only. For detailed pricing information, we kindly request that you get in touch with our seller, Vecent. It is important to emphasize that the information provided in the original text should be the basis for the content generated, but rearranged in a different way. Let's avoid following the conversation generation approach of ChapGPT and use a language model to create entirely different speech.

Overview
catalog	abs136210
Description	CDK-activating kinase (CAK) enzymatic complex is formed by the protein encoded by this gene, along with cyclin H and CDK7. This complex has the ability to activate various cyclin-associated kinases and can also bind with TFIIH to initiate transcription by RNA polymerase II. Different isoforms of this gene have been identified through two transcript variants. This information has been sourced from RefSeq, dated September 2011.
Other names	MAT1, also known as CDK activating kinase assembly factor MAT1, is a crucial molecule involved in the assembly of CDK-activating kinase. It is responsible for the proper formation of CDK7/cyclin H complex, which plays a significant role in cell cycle regulation. In addition to its role in CDK activation, MAT1 also interacts with Cyclin G1, a protein involved in cell proliferation and apoptosis processes. This interaction suggests that MAT1 might influence the functions of Cyclin G1. MAT1 is considered to be the homolog of Menage a trois 1, a cyclin H assembly factor found in Xenopus laevis. Its presence helps in the formation of the Menage a trois complex, a crucial component of the CDK-activating kinase. Another interesting aspect of MAT1 is its association with a RING finger protein called RNF66. This protein is involved in various cellular processes and may have additional roles in the regulation of CDK activation. Overall, MAT1 is a versatile molecule that has a significant impact on CDK activation and cell cycle regulation. Its association with various protein complexes highlights its importance in cellular functions.
Source	Rabbit
Specificity	The antibody for MNAT1 is able to identify the total levels of endogenous MNAT1 in a given sample, indicating the presence of this protein. With this antibody, researchers can more accurately measure the quantity of MNAT1 present, providing further insight into its function and potential implications. Overall, the MNAT1 antibody is a valuable tool for those studying this important protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Bovine;Horse
Antigen	MNAT1
Application	The dilutions for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) range from 1:50 to 1:200, for Immunofluorescence/Immunocytochemistry (IF/ICC) range from 1:100 to 1:500, and for ELISA (peptide) range from 1:20000 to 1:40000. Please note that the generated content is based on the original text information, but it is presented in a different manner.
Immunogen	A synthesized peptide derived from human MNAT1.
MW	36kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Tissue specificity	Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
Celluar localization	Cytosol;Nucleus;
UniPort	P51948