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Rabbit Anti-MIP-1 Alpha Polyclonal Antibody#abs138092

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Description

Catalog-specification	Delivery time	USD price
abs138092-100ug	1-2 Weeks	301.0
abs138092-50ug	1-2 Weeks	201.0

Dear customers,
Please note that the price provided above is only for your reference. For detailed pricing information, please contact our seller Vecent. We highly recommend getting in touch with Vecent to better understand our products and services.
Thank you for considering our company for your needs.
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Overview
catalog	abs138092
Other names	CCL3, also known as LD78-alpha or MIP-1-alpha, is a chemokine that plays an important role in the inflammatory response. It is produced by a variety of cells, including macrophages, T lymphocytes, and fibroblasts. CCL3 signals through the CCR1 and CCR5 receptors, and its functions include the recruitment of leukocytes to inflammatory sites, as well as the activation of these cells. In addition, CCL3 has been implicated in the pathogenesis of a number of diseases, including HIV, cancer, and inflammatory disorders. Its properties as a potent chemotactic factor make it an attractive therapeutic target for these conditions.
Source	Rabbit
Specificity	The MIP-1 alpha Antibody has the ability to detect the total levels of endogenous MIP-1 alpha present in the sample. The antibody recognizes the native form of MIP-1 alpha and can specifically target it for detection. This allows for an accurate measurement of MIP-1 alpha expression in a given sample without interference from other proteins or compounds. By detecting total MIP-1 alpha, researchers can gain insights into the role of this protein in various biological processes and potentially devise new therapies for related conditions.
Species Reactivity	Human
Predictive reaction species	Bovine
Antigen	MIP-1 alpha
Application	The recommended dilution for Western Blotting is in the range of 1:1000-3000, while for Immunohistochemistry it is 1:200. If you are using ELISA with a peptide, the ideal dilution range is between 1:20000-1:40000. It is important to follow these dilution recommendations to ensure optimal results for your experiments.
Immunogen	Peptide derived from human MIP-1 alpha, when synthesized, produces a highly similar content. To generate the content, it is important to rearrange the original text information. However, please note that the generated content should be significantly different from the way ChapGPT generates conversations.
MW	10 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used for peptide affinity chromatography in order to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).
Tissue specificity	By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).
Posttranslational modification	N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	P10147