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Rabbit Anti-MIB2 Polyclonal Antibody#abs132962

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Description

Catalog-specification	Delivery time	USD price
abs132962-100ug	1-2 Weeks	301.0
abs132962-50ug	1-2 Weeks	201.0

Overview
catalog	abs132962
Other names	MIB2, also known as E3 ubiquitin-protein ligase MIB2 or Mindbomb homolog 2, is a novel zinc finger protein with an intriguing combination of functional domains. It is sometimes referred to as Novelzin or Putative NF-kappa-B-activating protein 002N. MIB2 possesses a unique structure consisting of a zinc finger ZZ type with an ankyrin repeat domain, which gives it its distinctive characteristics. This protein is also designated as SKD or Skeletrophin due to its role in various biological processes. The MIB2 protein acts as an E3 ubiquitin ligase, which means it is involved in the regulation of protein degradation within cells. It plays a crucial role in the ubiquitin-proteasome pathway, which is responsible for maintaining cellular homeostasis by eliminating damaged or misfolded proteins. As an E3 ligase, MIB2 specifically recognizes and attaches ubiquitin molecules to target proteins, marking them for degradation. The zinc finger ZZ type domain present in MIB2 is a specialized DNA-binding domain found in many proteins involved in transcriptional regulation. It allows MIB2 to interact with specific DNA sequences and modulate gene expression. Additionally, the ankyrin repeat domain found in MIB2 is involved in protein-protein interactions, enabling MIB2 to interact with other molecules within the cell and regulate various signaling pathways. MIB2 has been found to play a role in the activation of NF-kappa-B, a crucial transcription factor involved in regulating various cellular processes, including immune responses and inflammation. Its interaction with NF-kappa-B suggests that MIB2 is involved in the modulation of these pathways. In summary, MIB2, also known as ZZANK1 or Skeletrophin, is a multifunctional protein with unique structural domains. Its role as an E3 ubiquitin ligase, along with its zinc finger and ankyrin repeat domains, allows MIB2 to regulate protein degradation, gene expression, and cell signaling pathways. Its involvement in NF-kappa-B activation highlights its importance in immune and inflammatory responses.
Source	Rabbit
Specificity	Total MIB2 can be detected at its natural levels using the MIB2 antibody. This antibody is specifically designed to recognize and bind to MIB2 protein, allowing for accurate detection and measurement of MIB2 levels.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Dog;Horse
Antigen	MIB2
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	110 kDa
Properties
Concentration	1mg/ml
purification	To obtain a purified antiserum, peptide affinity chromatography was employed with the use of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles. Proper storage conditions should be maintained to guarantee the product's longevity.
Storage buffer	IgG（pH 7.4）、150、0.02%50%。
Target
Background	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Tissue specificity	Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Posttranslational modification	Ubiquitinated. Possibly via autoubiquitination (By similarity).
Celluar localization	Cytosol;Endosome;
UniPort	Q96AX9