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Rabbit Anti-MDK Polyclonal Antibody#abs135574

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Description

Catalog-specification	Delivery time	USD price
abs135574-100ug	1-2 Weeks	301.0
abs135574-50ug	1-2 Weeks	201.0

Overview
catalog	abs135574
Description	Midkine, also known as MK, plays a crucial role in regulating growth and differentiation during embryonic development. It is a heparin-binding molecule with a mature human protein consisting of 118 amino acids. MK is a non-glycosylated protein that shares more than 87% identity between human and mouse. In embryonic development, MK expression is closely regulated by steroid receptors of the retinoic acid superfamily. Its carboxy-terminus contains the primary heparin-binding site and the neurite-promoting sequences, responsible for its neurotrophic properties. Both the amino- and carboxy-terminal sequences are required for these properties. Interestingly, MK overexpression has been linked to colon adenocarcinoma in families with familial polyposis. In addition, it enhances the activity of plasminogen activator (PA), which adds to its significance in regulating growth and differentiation. Overall, MK's involvement in embryonic development highlights its importance in the growth and differentiation of cells. Its association with colon adenocarcinoma and its ability to enhance PA's activity suggest its potential application in cancer therapy and fibrinolytic therapy.
Other names	Mdk, also known as Midkine or Neurite Growth Promoting Factor 2 (NEGF2), is an Amphiregulin Associated Protein (ARAP) with the alternative name of FLJ27379. ARAP plays a crucial role in promoting neurite outgrowth and is implicated in various biological processes. It is widely known as a retinoic acid inducible factor and is involved in midgestation and kidney development. This protein, known as MK, MK1, or MK_HUMAN, acts as a neurite outgrowth-promoting factor 2. Its significance lies in its ability to enhance the growth of neurites and promote the development of neural networks. This dynamic protein, also called Neurite Outgrowth-Promoting Protein, contributes to the intricate process of cell communication and neuronal differentiation. With its diverse roles and functions, Mdk exemplifies the complexity and sophistication of molecular mechanisms underlying cellular processes.
Source	Rabbit
Specificity	The presence of total MDK within an organism can be detected by using the MDK Antibody. This antibody has the ability to identify endogenous levels of MDK. If you rearrange the content above, it will still convey the same message about the antibody's detection capability.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Bovine
Antigen	MDK
Application	，1:5001:2000。，1:501:200。（ELISA），1:200001:40000。，。
Immunogen	A synthesized peptide derived from human MDK.
MW	16kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Tissue specificity	Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.
Celluar localization	Extracellular region or secreted;
UniPort	P21741