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Rabbit Anti-MASP2 Polyclonal Antibody#abs141230

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Description

Catalog-specification	Delivery time	USD price
abs141230-100ug	1-2 Weeks	301.0
abs141230-50ug	1-2 Weeks	201.0

Overview
catalog	abs141230
Other names	Lectin mannose-binding serine protease 2 (MBL-MASP2), also known as mannose-binding lectin serine peptidase 2 or mannose-binding protein associated serine protease 2, plays a crucial role in the immune system. It is encoded by the MAP19 gene and is also referred to as MAP19 or MASP2. Additionally, it is sometimes called MBL-associated plasma protein of 19 kD or MBL-associated serine protease 2. Another name for MBL-MASP2 is small MBL-associated protein or sMAP. This protein is involved in the activation of the lectin pathway of the complement system, which is essential for the recognition and clearance of pathogens. Rearranging the information, we can say that MBL-MASP2, also known as mannose-binding lectin serine peptidase 2 or mannose-binding protein associated serine protease 2, is encoded by the MAP19 gene and referred to as MAP19 or MASP2. It is involved in the activation of the lectin pathway of the complement system and is sometimes called MBL-associated plasma protein of 19 kD or MBL-associated serine protease 2. Another name for MBL-MASP2 is small MBL-associated protein or sMAP.
Source	Rabbit
Specificity	The antibody for MASP2 is capable of detecting the complete quantity of endogenous MASP2 protein.
Species Reactivity	Human;Mouse
Antigen	MASP2
Application	For Western blotting, dilute the primary antibody at a range of 1:500 to 1:1000. When performing IF/ICC, we suggest a dilution of 1:100 to 1:500. ELISA using a peptide substrate should be performed with the primary antibody diluted at a range of 1:20000 to 1:40000. These dilution recommendations will help achieve optimal results in your experiments.
Immunogen	A synthesized peptide.
MW	75 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum through peptide affinity chromatography. To ensure a highly similar content, the generated content may include information about the resin being employed in the purification procedure.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the sample, it is recommended to store it at a temperature of -20 °C for a period of one year. It is essential to avoid subjecting the sample to repeated freeze and thaw cycles, as this may result in degradation of the specimens. Take the necessary precautions to ensure that the sample remains stable and free from damage.
Storage buffer	The Rabbit IgG is suspended in a solution of phosphate buffered saline that has a pH of 7.4, along with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store this solution at a temperature of -20 °C, where it can remain stable for up to 12 months from the date of receipt. These unique characteristics of the solution make it an ideal choice for various laboratory and research applications.
Target
Background	Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
Tissue specificity	Plasma.
Posttranslational modification	The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
Celluar localization	Extracellular region or secreted;
UniPort	O00187