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Rabbit Anti-MAP3K15 Polyclonal Antibody#abs138362

Description

Catalog-specification	Delivery time	USD price
abs138362-100ug	1-2 Weeks	301.0
abs138362-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138362
Other names	ASK3, also known as apoptosis signal-regulating kinase 3, is a protein encoded by the gene Map3k15. It is a member of the mitogen-activated protein kinase kinase kinase family and plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. ASK3 is also known as MEK kinase 15 or MEKK15 and is involved in activating the JNK and p38 MAPK pathways. It is highly expressed in many tissues, including the brain, heart, and kidney. The function of ASK3 is regulated by various mechanisms, including phosphorylation, protein-protein interactions, and subcellular localization. Dysregulation of ASK3 has been associated with several diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Overall, ASK3 is an essential component of the MAPK signaling pathway and plays a critical role in the regulation of cellular processes. Its function and dysregulation have significant implications for understanding and treating various diseases.
Source	Rabbit
Specificity	The MAP3K15 Antibody is capable of detecting the total levels of endogenous MAP3K15 protein. An antibody specifically targets and binds to a particular protein, allowing researchers to observe and measure its expression levels in a sample. In this case, the antibody is designed to recognize MAP3K15, a protein that plays a role in cellular signal transduction pathways. The detection of endogenous MAP3K15 levels enables scientists to investigate its function and potential implications in various biological processes.
Species Reactivity	Human
Antigen	MAP3K15
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human MAP3K15.
MW	147 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in purifying the antiserum. Let me generate a distinct content based on the original text information: The purification of the antiserum involved the application of SulfoLink™ Coupling Resin for peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal quality, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze/thaw cycles as this may affect its stability and efficacy.
Storage buffer	This solution of Rabbit IgG comes in a phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal preservation, store at a temperature of -20°C. The shelf life of this product is guaranteed for a period of 12 months from the date of receipt.
Target
Background	May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis.
Tissue specificity	Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen.
UniPort	Q6ZN16