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Rabbit Anti-CPA4 Polyclonal Antibody#abs138856

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Description

Catalog-specification	Delivery time	USD price
abs138856-100ug	1-2 Weeks	301.0
abs138856-50ug	1-2 Weeks	201.0

Overview
catalog	abs138856
Other names	There are two carboxypeptidases, namely Carboxypeptidase A3 and Carboxypeptidase A4, that are found in humans. Both of these enzymes belong to the carboxypeptidase family and are involved in the cleavage of peptide bonds. CBPA4_HUMAN or Carboxypeptidase A4 is an enzyme that is found in humans and is encoded by the CPA4 gene. This enzyme is also known as CPA3 or Cpa4 and plays a crucial role in the catalysis of carboxypeptidase A substrates. Overall, these carboxypeptidases are essential for various biological processes and play a crucial role in maintaining the overall homeostasis of the human body. By cleaving peptide bonds, these enzymes aid in the breakdown of proteins and ensure that amino acids are available for vital physiological processes such as neurotransmitter synthesis, hormone synthesis, and the immune response.
Source	Rabbit
Specificity	The total CPA4 in the system can be detected using the CPA4 Antibody. This antibody has the ability to recognize and bind to the endogenous levels of CPA4, allowing for accurate detection. It is important to note that this antibody only detects the total amount of CPA4, and not any specific isoforms or variants.
Species Reactivity	Human;Mouse
Antigen	CPA4
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CPA4.
MW	47 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles, as this can compromise its integrity. So, make sure to adhere to these guidelines to maintain the quality of the product over time.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline, with a pH of 7.4, as well as 150mM NaCl and 0.02% sodium azide. It is also mixed with 50% glycerol and should be stored at -20 °C. The product has a shelf life of 12 months from the date of receipt. Please note that this information is based on the original text provided.
Target
Background	According to a study published in PubMed (PubMed:10383164), there is a metalloprotease that plays a role in the pathway of histone hyperacetylation. This metalloprotease is responsible for releasing a C-terminal amino acid, and it shows a preference for amino acids such as -Phe, -Leu, -Ile, -Met, -Tyr, and -Val (PubMed:20385563). The findings suggest that this metalloprotease may contribute to the regulation of histone acetylation levels, potentially influencing gene expression and cellular processes. Further research is needed to fully understand the mechanisms and implications of this metalloprotease in the histone hyperacetylation pathway.
Tissue specificity	Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.
Celluar localization	Extracellular region or secreted;
UniPort	Q9UI42