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Rabbit Anti-RAD23B Polyclonal Antibody#abs134947

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Description

Catalog-specification	Delivery time	USD price
abs134947-100ug	1-2 Weeks	301.0
abs134947-50ug	1-2 Weeks	201.0

Overview
catalog	abs134947
Other names	RAD23B is a versatile protein involved in DNA repair processes. It is also known as hHR 23B, HR23B, mHR 23B, p58, RAD 23B, RAD23 homolog B, and XP C repair complementing complex 58 kDa protein. RAD23B is a homolog of the yeast protein RAD23 and plays a crucial role in the recognition and removal of damaged DNA. This protein is essential for nucleotide excision repair, a mechanism that corrects DNA damage caused by UV radiation and other genotoxic agents. RAD23B interacts with other proteins to form the XPC repair complementing complex, which is responsible for initiating the DNA repair process. Dysfunction of RAD23B can lead to the accumulation of DNA damage and increase the risk of genomic instability and cancer development. Understanding the functions and regulation of RAD23B is imperative for elucidating the molecular mechanisms underlying DNA repair and maintaining genomic integrity.
Source	Rabbit
Specificity	The RAD23B Antibody is designed to recognize total RAD23B levels in the body. It can detect endogenous levels of the protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	RAD23B
Application	For Western blotting, a dilution of 1:500 to 1:1000 is recommended. For immunofluorescence and immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. If you are using ELISA with peptides, a dilution of 1:20000 to 1:40000 can be used. It is important to note that these dilution recommendations are based on the original text information.
Immunogen	A synthesized peptide.
MW	58/50 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
Celluar localization	Cytosol;Nucleus;
UniPort	P54727