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Rabbit Anti-LYPLA1 Polyclonal Antibody#abs140816

Please note that the price mentioned is only for your reference. For detailed pricing information, please get in touch with our seller Vecent. It's important to clarify that the generated content should not follow the same patterns as ChapGPT, but rather, should use a language model to create...

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Description

Catalog-specification	Delivery time	USD price
abs140816-100ug	1-2 Weeks	301.0
abs140816-50ug	1-2 Weeks	201.0

Overview
catalog	abs140816
Other names	APTs, also known as Acyl-protein thioesterase 1, are enzymes that play a crucial role in cellular processes. Specifically, APT 1, or APT-1, also referred to as hAPT1 or LPL-I, belongs to the LYPLA1 family of proteins. LYPLA1 stands for lysophospholipase 1, which is an enzyme involved in lysophospholipid metabolism. The main function of APT 1 is to catalyze the hydrolysis of fatty acyl groups from protein substrates. This process, known as deacylation, is important for regulating protein localization, stability, and function. APT 1 achieves this by breaking the thioester bond between the fatty acyl group and the protein, resulting in the release of free fatty acids. Apart from its role in regulating protein fatty acylation, APT 1 is also involved in lysophospholipid metabolism. It acts as a lysophospholipid-specific lysophospholipase, catalyzing the hydrolysis of lysophospholipids into lysophosphatidic acid (LPA) and a free fatty acid. The significance of APT 1 and its enzymatic activity extends to various cellular processes. Proper regulation of protein fatty acylation and lysophospholipid metabolism is essential for cell signaling, membrane trafficking, lipid homeostasis, and other fundamental cellular functions. In summary, APT 1, or Acyl-protein thioesterase 1, is an enzyme involved in the hydrolysis of acyl groups from protein substrates. It plays a crucial role in regulating protein fatty acylation and lysophospholipid metabolism, thereby impacting various cellular processes.
Source	Rabbit
Specificity	The detection of total LYPLA1 is possible using the LYPLA1 Antibody that specifically targets endogenous levels of the protein. It is important to note that this antibody can accurately identify and measure the overall amount of LYPLA1 present in a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Xenopus;Sheep;Bovine;Rabbit;Zebrafish;
Antigen	LYPLA1
Application	WB1：500~1：1000，IF/ICC1：100-1：500，ELISA（）1：20000-1：40000。，，。ChapGPT，。
Immunogen	A synthesized peptide.
MW	25 KD
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at -20 °C for up to one year. Care should be taken to avoid subjecting the product to repeated freezing and thawing cycles as this can compromise the integrity of the product. By following these guidelines, you can ensure the product remains effective for its intended use.
Storage buffer	This product contains rabbit IgG in a solution of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It must be stored at temperatures of -20°C or lower, and will remain stable for up to 12 months from the date of receipt.
Target
Background	Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;
UniPort	O75608