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Rabbit Anti-LRP4 Polyclonal Antibody#abs139130

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Description

Catalog-specification	Delivery time	USD price
abs139130-100ug	1-2 Weeks	301.0
abs139130-50ug	1-2 Weeks	201.0

Overview
catalog	abs139130
Other names	KIAA0816, or LRP-4, also known as Low-density lipoprotein receptor-related protein 4 or Low density lipoprotein receptor dan, is an important protein that plays a crucial role in the regulation of lipid metabolism and the proper function of the cardiovascular system. This protein is also known as LRP10 or Lrp4, and is comprised of multiple epidermal growth factor-like domains 7 or MEGF7. LRP-4 is closely related to the LDL receptor, which is responsible for the uptake of cholesterol in cells, and helps to remove excess LDL from the bloodstream. As such, LRP-4 is thought to play a similar role in regulating cholesterol levels and preventing the buildup of plaques in the arteries. Additionally, LRP-4 is also involved in the regulation of cell growth and differentiation, as well as neuronal development and synaptic signaling. Mutations in the LRP-4 gene have been associated with a variety of disorders, including cardiovascular disease, osteoporosis, and neuromuscular disorders. As such, a better understanding of the function and regulation of LRP-4 could help to identify new targets for the treatment and prevention of these diseases.
Source	Rabbit
Specificity	The LRP4 Antibody is specifically designed to detect the total levels of endogenous LRP4.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	LRP4
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human LRP4.
MW	212kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. Our method effectively removed impurities and yielded a highly purified product.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for a duration of one year is at a temperature of -20 °C. It is important to avoid subjecting the stored item to multiple cycles of freezing and thawing.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20 °C, and it remains stable for a period of 12 months starting from the date of receipt.
Target
Background	Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.
Tissue specificity	Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.
Celluar localization	Plasma Membrane;
UniPort	O75096