Rabbit Anti-LAMP3 Polyclonal Antibody#abs136619
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Description
| Catalog-specification | Delivery time | USD price |
abs136619-100ug | 1-2 Weeks | 301.0 |
abs136619-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference purposes only. For detailed pricing information, kindly get in touch with our seller, Vecent. I urge you to avoid using ChapGPT to generate content in a similar manner and instead adopt a completely different approach when communicating.
| Overview | |
catalog | abs136619 |
Description | The LAMP3 gene encodes the lysosome-associated membrane glycoprotein 3, also known as CD208. This critical protein is involved in dendritic cell (DC) function and adaptive immunity. DCs are essential antigen-presenting cells that capture antigens and differentiate into interdigitating dendritic cells within lymphoid tissues, where they trigger primary T-cell responses. LAMP3 is thought to play an integral role in this process, making it a target of interest for researchers studying the immune system. Understanding the function of LAMP3 and its relationship to DCs could lead to new insights into how we can harness the body's natural defenses to fight disease. |
| Other names | DC-lysosome-associated membrane glycoprotein, also known as CD208 or LAMP-3, is a protein that plays a role in lysosomal function. It is a glycoprotein associated with the membrane of lysosomes within dendritic cells (DCs). LAMP-3 is encoded by the LAMP3 gene and is involved in various cellular processes. Another name for LAMP-3 is DC LAMP, which stands for DC lysosome-associated membrane glycoprotein. This protein is specifically expressed in DCs and is crucial for their lysosomal function. LAMP-3 is also referred to as CD208 antigen, reflecting its identification as a unique surface marker for DCs. LAMP-3, or lysosomal-associated membrane protein 3, is a member of the LAMP family of proteins. It shares homology with other LAMP proteins, which are involved in the regulation of lysosomal processes. LAMP-3 is localized to the lysosomal membrane and is implicated in endocytic trafficking and antigen presentation. LAMP-3 is also known by the name protein TSC403, indicating its association with the tuberous sclerosis complex (TSC) pathway. The exact role of LAMP-3 in TSC is still being investigated, but it may be related to the regulation of lysosomal function and cellular growth. In summary, LAMP-3, or CD208 antigen, is a DC-specific glycoprotein localized to the lysosomal membrane. It plays a critical role in lysosomal function and is involved in various cellular processes within DCs. Additionally, LAMP-3 is associated with the TSC pathway and may contribute to the regulation of cellular growth. |
| Source | Rabbit |
| Specificity | The LAMP3 Antibody is capable of recognizing the overall levels of naturally occurring LAMP3 protein in an organism. This detection tool is able to accurately determine the presence of LAMP3 without interference from other proteins or factors. By utilizing this antibody, researchers are able to monitor the dynamics of LAMP3 protein expression and decipher its role in various biological processes. Overall, this tool provides an essential means of investigating the function and regulation of LAMP3 in vivo. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | LAMP3 |
| Application | The dilution ranges for this antibody are WB 1:500-1:2000, IHC 1:50-1:100, and ELISA (peptide) 1:20000-1:40000. To ensure accurate and reliable results, it is recommended to use within these dilution ranges. When performing Western blotting, dilute the antibody at a ratio of 1:500-1:2000. For immunohistochemistry, the recommended dilution is between 1:50-1:100. For ELISA (peptide) experiments, dilute the antibody at a ratio of 1:20000-1:40000. These dilution ranges have been optimized by our team of scientists for optimal performance and specificity. |
| Immunogen | A synthetic peptide of humanLAMP3. |
| MW | 44kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. To achieve this, the resin was able to effectively couple with peptides in the antiserum, resulting in a highly purified final product. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | May play a role in dendritic cell function and in adaptive immunity. |
| Tissue specificity | Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. |
| Celluar localization | Endosome;Lysosome;Nucleus;Plasma Membrane; |
| UniPort | Q9UQV4 |
Western blot analysis of extracts of HT-29 cellline, using LAMP3antibody|Immunohistochemistryof paraffin-embeddedhuman thyroid cancer tissue usingLAMP3antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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