Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-KHSRP Polyclonal Antibody#abs139034

Note: Please be aware that the price mentioned above is purely for your reference. For detailed pricing information, we kindly request you to get in touch with our sales representative, Vecent. In order to generate a substantially different form of speech, we will not follow the conversational...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs139034-100ug	1-2 Weeks	301.0
abs139034-50ug	1-2 Weeks	201.0

Overview
catalog	abs139034
Other names	FBP2, also known as Far upstream element-binding protein 2, is a KH type splicing regulatory protein that plays a crucial role in gene regulation. It is also referred to as FUBP2, FUBP2_HUMAN, FUSE binding protein 2, FUSE-binding protein 2, KHSRP, KSRP, and p75. FBP2 is involved in binding to the Far Upstream Element (FUSE) of certain promoters, thereby regulating transcription. This protein possesses KH domains, which are RNA-binding motifs that contribute to its splicing regulatory function. FBP2's ability to interact with FUSE is essential for the efficient transcription of target genes. Therefore, FBP2 plays a significant role in the control of gene expression and is crucial for various cellular processes.
Source	Rabbit
Specificity	The KHSRP Antibody is designed to recognize and measure the levels of total KHSRP protein present in cells. It specifically targets the endogenous KHSRP protein, allowing for accurate detection. By using this antibody, researchers are able to study the expression and regulation of KHSRP in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Xenopus;Chicken;Sheep;Bovine;Horse;
Antigen	KHSRP
Application	For Western blot, a dilution of 1:1000-3000 is recommended, while for immunohistochemistry a dilution of 1:200 is recommended. For immunofluorescence and immunocytochemistry, dilutions of 1:100-1:500 are appropriate. For ELISA assays using peptide antigens, a dilution range of 1:20000-1:40000 should provide optimal results. It is important to note that careful optimization of dilution is necessary for each individual experiment to ensure optimal performance of the antibody.
Immunogen	A synthesized peptide derived from human KHSRP.
MW	73 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was used in peptide affinity chromatography for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One year storage is recommended at -20 °C, without subjecting to repeated freeze/thaw cycles. It is important to avoid following the content generation approach of ChapGPT, and instead focus on delivering a speech using a completely different linguistic style based on the provided information.
Storage buffer	The storage solution for Rabbit IgG is composed of phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store it at -20 °C. This solution remains stable for a period of 12 months from the date of receipt.
Target
Background	Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Tissue specificity	Detected in neural and non-neural cell lines.
Posttranslational modification	Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.
Celluar localization	Cytosol;Nucleus;
UniPort	Q92945