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Rabbit Anti-KHDRBS3 Polyclonal Antibody#abs139118

Description

Catalog-specification	Delivery time	USD price
abs139118-100ug	1-2 Weeks	301.0
abs139118-50ug	1-2 Weeks	201.0

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Overview
catalog	abs139118
Other names	The RNA binding protein T-Star, also known as KH Domain Containing RNA Binding Signal Transduction Associated 3, or KHDR3, is a Sam68-like phosphotyrosine protein that plays a role in signal transduction. Its RNA-binding capabilities make it an important factor in gene expression regulation. Additionally, T-Star has been associated with the Sam68-like mammalian protein 2, or SLM-2, which further highlights its significance in cellular processes. T-Star is an essential protein for proper cellular function and its dysregulation has been linked to various diseases.
Source	Rabbit
Specificity	The KHDRBS3 Antibody is designed to specifically recognize and measure the levels of total KHDRBS3 protein present in a biological sample. It is capable of detecting the endogenous expression of KHDRBS3, providing valuable insights into its overall abundance. By utilizing the KHDRBS3 Antibody, researchers can gain a comprehensive understanding of the role and regulation of KHDRBS3 in various biological processes.
Species Reactivity	Human;Mouse;Rat
Antigen	KHDRBS3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human KHDRBS3.
MW	39 kDa
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. It was a highly effective method that ensured the removal of impurities and resulted in the production of a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a year. It is important to avoid subjecting the product to repeated freeze and thaw cycles which can compromise its integrity and effectiveness. Therefore, it is advisable to handle the product with care and store it in appropriate conditions to ensure long-term stability.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation.
Tissue specificity	Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.
Posttranslational modification	Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.
Celluar localization	Nucleus;
UniPort	O75525