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Rabbit Anti-JAM3 Polyclonal Antibody#abs138519

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Description

Catalog-specification	Delivery time	USD price
abs138519-100ug	1-2 Weeks	301.0
abs138519-50ug	1-2 Weeks	201.0

Overview
catalog	abs138519
Other names	Junctional adhesion molecule 3 (JAM-3) is a protein encoded by the FLJ14529 gene. It is also known as JAM C or JAMC. The precursor form of JAM-3 is expressed as JAM2, JAM3, or JAM-2, while the mature form is referred to as JAM3_HUMAN. This protein plays a crucial role in cellular adhesion at junctional sites. Its presence facilitates the formation of tight junctions between cells, ensuring their proper alignment and stability. By rearranging the given information, a comprehensive understanding of JAM-3 and its various names can be gained.
Source	Rabbit
Specificity	The endogenous levels of total JAM3 can be detected using the JAM3 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	JAM3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human JAM3.
MW	35 kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. Through this process, the antiserum was carefully isolated and concentrated, resulting in a highly potent and effective product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20°C for a period of one year. It is important to avoid repeated cycles of freezing and thawing, as this can have a negative impact on the product's effectiveness. It is therefore important to store the product in a location where the temperature remains consistent, to ensure that its quality is maintained over time. By following these guidelines, you can ensure that the product remains effective and usable for an extended period of time.
Storage buffer	The Rabbit IgG provided in this package is dissolved in a buffer solution consisting of phosphate buffered saline with a pH value of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. In order to preserve its quality, it is recommended that the product be stored at -20 °C. This product is considered stable for a period of 12 months from the date it is received, ensuring that you get the most use out of it.
Target
Background	Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis.
Tissue specificity	Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level).
Posttranslational modification	Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by proinflammatory factors.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q9BX67