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Rabbit Anti-ITFG2 Polyclonal Antibody#abs138517

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Description

Catalog-specification	Delivery time	USD price
abs138517-100ug	1-2 Weeks	301.0
abs138517-50ug	1-2 Weeks	201.0

Overview
catalog	abs138517
Other names	Integrin alpha FG GAP repeat containing 2, also known as ITFG 2 or Integrin alpha FG GAP repeat containing protein 2, is a protein that plays an important role in the functioning of hematopoietic stem cells. It is characterized by its multiple alpha FG GAP repeats and is expressed in various tissues including the bone marrow. MDS 028, a gene expression profile associated with myelodysplastic syndrome, has been found to include ITFG 2. Despite its significance in stem cell regulation, little is known about the precise mechanisms by which ITFG 2 acts. Nonetheless, researchers continue to investigate this enigmatic protein and its potential implications for the diagnosis and treatment of various hematological disorders.
Source	Rabbit
Specificity	The endogenous levels of total ITFG2 can be detected by the ITFG2 Antibody.
Species Reactivity	Human;Mouse
Antigen	ITFG2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ITFG2.
MW	49 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin to perform peptide affinity chromatography and purify the antiserum. This allowed us to isolate a highly specific and targeted product.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is essential to store it at -20 °C for a duration of one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	This is a description of Rabbit IgG which is suspended in a solution of phosphate buffered saline with a pH value of 7.4. In addition to that, there is a concentration of 150 millimolar sodium chloride and 0.02% sodium azide which is added to enhance stability. The mixture is further stabilized with 50% glycerol and should be stored at a temperature of -20°C. It is important to note that the shelf life of this product is approximately one year from the date of receipt.
Target
Background	As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Celluar localization	Cytosol;Lysosome;Nucleus;
UniPort	Q969R8