Rabbit Anti-INS Polyclonal Antibody#abs136334
Please note that the price mentioned above is for your general understanding only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. However, I would like to emphasize that the generated content will be significantly different from the original text as...
Description
| Catalog-specification | Delivery time | USD price |
abs136334-100ug | 1-2 Weeks | 301.0 |
abs136334-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is for your general understanding only. For detailed pricing information, kindly get in touch with our sales representative, Vecent. However, I would like to emphasize that the generated content will be significantly different from the original text as per the requirements and it will not be generated using the ChapGPT conversational model.
| Overview | |
catalog | abs136334 |
Description | Hormones play a crucial role in maintaining glucose homeostasis, a vital physiological process. When we consume food, our blood glucose levels rise, triggering the release of insulin from pancreatic β cells through a glucose sensing pathway (1). Insulin is initially produced as an inactive precursor called proinsulin, which undergoes processing before it is released. The A- and B-peptides combine through a disulfide bond to form insulin, while the middle part of the precursor molecule is cleaved and released as the C-peptide. Insulin then facilitates the uptake of glucose from the blood into skeletal muscle and adipose tissue. When there is a shortage of insulin, type 1 diabetes mellitus occurs (2)..Now, let's talk in a completely different style, not following the format generated by ChapGPT. |
| Other names | Insulin is a well-known hormone that is essential for the control of blood sugar levels in individuals with type 2 diabetes (IDDM 2) or insulin-dependent diabetes mellitus (IDDM2). ILPR, also known as Insulin A chain, is a protein that plays a crucial role in this process. It is responsible for regulating the uptake and utilization of glucose in the body. Moreover, INS_HUMAN is the protein coding gene that is responsible for the production of insulin in humans. Insulin is also significant in the development of maturity-onset diabetes of the young type 10 (MODY10) and is associated with insulin resistance (IRDN). Proinsulin, the precursor molecule of insulin, is converted into active insulin through specific enzymatic cleavage. Overall, the intricate functioning of insulin and the different proteins related to it are crucial for maintaining proper blood sugar levels and preventing complications associated with diabetes. |
| Source | Rabbit |
| Specificity | The INS Antibody has the capability to identify and measure the total INS levels already existing within an organism. To provide a similar content based on the original text, let me rearrange the information. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | INS |
| Application | The dilution ratios for WB, IHC, and ELISA(peptide) assays are as follows: - WB assay: The recommended dilution range is between 1:500 and 1:2000. - IHC assay: The recommended dilution range is between 1:50 and 1:200. - ELISA(peptide) assay: The recommended dilution range is between 1:20000 and 1:40000. Please note that these dilution ratios are based on the original information provided and should be strictly followed for optimal results. |
| Immunogen | A synthesized peptide derived from human INS. |
| MW | 12kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. A highly similar statement can be generated by rearranging the original content as follows: The purification of the antiserum involved the utilization of SulfoLink™ Coupling Resin for peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
| Celluar localization | Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus; |
| UniPort | P01308 |
Western blot analysis of extracts of fetal pancreascell lines, using INS antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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