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Rabbit Anti-INAR2 Polyclonal Antibody#abs132914

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Description

Catalog-specification	Delivery time	USD price
abs132914-100ug	1-2 Weeks	301.0
abs132914-50ug	1-2 Weeks	201.0

Overview
catalog	abs132914
Other names	The human interferon alpha/beta receptor is known by various names, such as IFN alpha REC, IFN R, IFN-a/ßR2, IFN-a/ßRß, IFN-alpha binding protein, IFN-alpha/beta receptor 2, IFN-R-2, IFNABR, IFNAR2, IFNARB, IFNR, INAR2_HUMAN, Interferon (alpha beta and omega) receptor 2, Interferon alpha binding protein, Interferon alpha/beta receptor 2, Interferon alpha/beta receptor beta chain, Type I interferon receptor 2, and Type I interferon receptor. These different names denote the same receptor that is involved in responding to interferon alpha and beta signals. Its function is to bind and facilitate the actions of interferons, which play a vital role in immune responses and antiviral defense. By rearranging the provided information, the content remains true to the original text.
Source	Rabbit
Specificity	The INAR2 antibody is capable of identifying the overall amount of INAR2 present within an organism's system. This antibody recognizes and binds to endogenous levels of total INAR2.
Species Reactivity	Human;Rat
Antigen	INAR2
Application	The dilution range for Western blotting is 1:500-1:2000, for immunohistochemistry is 1:50-1:200, and for ELISA (peptide) is 1:20000-1:40000.
Immunogen	A synthesized peptide.
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality and effectiveness of your product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that repeated freeze/thaw cycles should be avoided in order to prevent any potential damage to the product. By following these storage guidelines, you can ensure that your product remains stable and effective for its intended use.
Storage buffer	：（pH 7.4，150 mM NaCl，0.02％50％），IgG。
Target
Background	Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation (PubMed:26424569). Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Tissue specificity	Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Posttranslational modification	Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.Glycosylated.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P48551