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Rabbit Anti-IL17RA Polyclonal Antibody#abs140681

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Description

Catalog-specification	Delivery time	USD price
abs140681-100ug	1-2 Weeks	301.0
abs140681-50ug	1-2 Weeks	201.0

Overview
catalog	abs140681
Other names	IL-17 receptor A, also known as CD217 or CDw217, is a cell surface protein that plays a crucial role in the immune system. It is encoded by the IL17RA gene and is involved in mediating the effects of IL-17, a pro-inflammatory cytokine. IL-17 receptor A is also referred to as CTLA8 or HIL 17R. IL-17 receptor A, abbreviated as IL-17RA, is a receptor for IL-17 and is expressed on a variety of cell types, including immune cells, endothelial cells, and epithelial cells. It is a transmembrane protein that consists of several domains, including an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain is responsible for binding IL-17 and initiating downstream signaling pathways. IL-17 receptor A is important in the regulation of inflammation and immune responses. When IL-17 binds to IL-17 receptor A, it triggers a signaling cascade that leads to the activation of various immune cells and the production of cytokines and chemokines. This, in turn, promotes inflammation and recruits immune cells to the site of infection or tissue damage. IL-17 receptor A has been implicated in several diseases, including autoimmune diseases, chronic inflammatory disorders, and certain types of cancer. Dysregulation of IL-17 receptor A signaling can contribute to the development and progression of these diseases. In summary, IL-17 receptor A, also known as CD217 or CDw217, is an important player in the immune system, mediating the effects of IL-17 and regulating inflammation and immune responses. Understanding the function and regulation of IL-17 receptor A could provide insights into the development of therapeutic strategies for various diseases.
Source	Rabbit
Specificity	The IL17RA Antibody can detect the complete amount of IL17RA that is present in an organism naturally.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Pig;Dog;Bovine;
Antigen	IL17RA
Application	For Western Blot, it is recommended to dilute the antibody at 1:500 to 1:1000. When performing Immunofluorescence or Immunocytochemistry, a dilution of 1:100 to 1:500 is suggested. For ELISA using a peptide, it is recommended to dilute the antibody at 1:20000 to 1:40000. These dilution recommendations will help ensure successful detection of your target protein in your experimental samples.
Immunogen	A synthesized peptide.
MW	90 KD
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography utilizing SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	One should store the product at a temperature of -20°C for a duration of one year. One must also avoid exposing the product to repeated freeze and thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG include storing it at -20°C in a solution of phosphate buffered saline with a pH of 7.4. The solution should also contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of Rabbit IgG is guaranteed for a period of 12 months from the date of receipt.
Target
Background	Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).
Tissue specificity	Widely expressed.
Posttranslational modification	Glycosylated.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q96F46