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Rabbit Anti-Ik3-1 Polyclonal Antibody#abs138188

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Description

Catalog-specification	Delivery time	USD price
abs138188-100ug	1-2 Weeks	301.0
abs138188-50ug	1-2 Weeks	201.0

Overview
catalog	abs138188
Other names	CABLES; CABLES1; Cdk5 and Abl enzyme substrate 1, also known as CABL1_HUMAN, is a protein that acts as a substrate for the enzymes CDK5 and ABL1. It is encoded by the gene FLJ35924, which is also sometimes referred to as HsT2563. Another name for this protein is IK3 1 or Ik3-1, as it interacts with CDK3. This information can be rearranged to form a different but highly similar content.
Source	Rabbit
Specificity	The Ik3-1 Antibody is specifically designed to recognize and measure the levels of total Ik3-1 in natural cell samples. Its primary function is to detect endogenous amounts of Ik3-1 protein. By utilizing this antibody, researchers can accurately gauge the presence of Ik3-1 within experimental settings.
Species Reactivity	Human;Mouse
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep;Horse;
Antigen	Ik3-1
Application	Our recommended dilution ratio for Western Blotting is between 1:1000-3000, while for IF/ICC staining, we suggest a dilution of 1:100-1:500. When using ELISA assays with a peptide substrate, a dilution ratio of 1:20000-1:40000 is most effective. These guidelines are based on the original text information and should be followed for optimal results.
Immunogen	A synthesized peptide derived from human Ik3-1.
MW	67 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advised to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze and thaw cycles. It is recommended to follow this storage guideline to preserve the product's properties.
Storage buffer	This Rabbit IgG solution is formulated in phosphate buffered saline at pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal storage conditions, store the solution at -20 °C, as it remains stable for up to 12 months from the date of receipt.
Target
Background	Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).
Tissue specificity	Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
Posttranslational modification	Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).
Celluar localization	Cytosol;Nucleus;
UniPort	Q8TDN4