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Rabbit Anti-HIPK1 Polyclonal Antibody#abs138367

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Description

Catalog-specification	Delivery time	USD price
abs138367-100ug	1-2 Weeks	301.0
abs138367-50ug	1-2 Weeks	201.0

Overview
catalog	abs138367
Other names	HIPK1, also known as homeodomain interacting protein kinase 1, is a protein involved in various cellular processes. Another related protein is the homeodomain interacting protein kinase 1 like protein. HIPK1 is also referred to as Myak and Nbak2, which stands for nuclear body associated kinase 2. Additionally, there is a variant called nuclear body-associated kinase 2b. These proteins play important roles in cellular signaling and regulation.
Source	Rabbit
Specificity	The detection of endogenous levels of total HIPK1 is made possible by the HIPK1 Antibody. By rearranging the provided content, we can generate similar information: The total HIPK1 present in the system can be accurately identified using the HIPK1 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	HIPK1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human HIPK1.
MW	131 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. The purification process involved rearranging the above content to ensure a highly similar output while maintaining the original information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, store the item at a temperature of -20 °C for one year. It is important to avoid subjecting it to multiple freeze/thaw cycles.
Storage buffer	The rabbit IgG is stored in a solution of phosphate buffered saline at pH 7.4. It also contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20 °C, and it is stable for up to 12 months from the date of receipt. Please note that the content generated by using a language model should be significantly different from the original text.
Target
Background	Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.
Tissue specificity	Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis.
Posttranslational modification	Autophosphorylated. Phosphorylated and activated by JNK1.Degraded by PARK7 at the protein level.Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q86Z02